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1qk6

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{{Seed}}
 
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[[Image:1qk6.png|left|200px]]
 
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==Solution structure of huwentoxin-I by NMR==
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The line below this paragraph, containing "STRUCTURE_1qk6", creates the "Structure Box" on the page.
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<StructureSection load='1qk6' size='340' side='right'caption='[[1qk6]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1qk6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cyriopagopus_schmidti Cyriopagopus schmidti]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QK6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qk6 OCA], [https://pdbe.org/1qk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qk6 RCSB], [https://www.ebi.ac.uk/pdbsum/1qk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qk6 ProSAT]</span></td></tr>
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{{STRUCTURE_1qk6| PDB=1qk6 | SCENE= }}
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</table>
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== Function ==
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===SOLUTION STRUCTURE OF HUWENTOXIN-I BY NMR===
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[https://www.uniprot.org/uniprot/TXH1_CYRSC TXH1_CYRSC] Lethal toxin with multiple biological activities. Inhibits voltage-gated TTX-sensitive sodium channels in DRG neurons (IC(50)=55 nM) and also shows activity when directly tested on Nav1.7/SCN9A (IC(50)=25.1-630 nM) (PubMed:17451655, PubMed:21731778, PubMed:31234412). Inhibits N-type calcium channels (Cav2.2/CACNA1B (IC(50)=100 nM)) (PubMed:11024489, PubMed:17451655). Also blocks neuromuscular transmission (PubMed:8212049, PubMed:9028007, PubMed:10736477). In vivo, intrathecal injected toxin shows analgesic activity in the rat formalin-induced pain model, without induction of motor dysfunction in rats.<ref>PMID:15581678</ref>
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== References ==
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<references/>
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 9263120 is the PubMed ID number.
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[[Category: Cyriopagopus schmidti]]
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_9263120}}
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[[Category: Ding J]]
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[[Category: Gu X]]
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==About this Structure==
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[[Category: Liang S]]
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1QK6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithoctonus_huwena Ornithoctonus huwena]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QK6 OCA].
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[[Category: Liu X]]
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[[Category: Qu Y]]
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==Reference==
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[[Category: Zhang R]]
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Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spider Selenocosmia huwena: 2. Three-dimensional structure in solution., Qu Y, Liang S, Ding J, Liu X, Zhang R, Gu X, J Protein Chem. 1997 Aug;16(6):565-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9263120 9263120]
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[[Category: Ornithoctonus huwena]]
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[[Category: Single protein]]
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[[Category: Ding, J.]]
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[[Category: Gu, X.]]
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[[Category: Liang, S.]]
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[[Category: Liu, X.]]
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[[Category: Qu, Y.]]
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[[Category: Zhang, R.]]
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[[Category: Cystine knot]]
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[[Category: Huwentoxin-i]]
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[[Category: Spider]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:38:00 2008''
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Current revision

Solution structure of huwentoxin-I by NMR

PDB ID 1qk6

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