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1rcw

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[[Image:1rcw.png|left|200px]]
 
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{{STRUCTURE_1rcw| PDB=1rcw | SCENE= }}
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==Crystal structure of CT610 from Chlamydia trachomatis==
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<StructureSection load='1rcw' size='340' side='right'caption='[[1rcw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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===Crystal structure of CT610 from Chlamydia trachomatis===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1rcw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydia_trachomatis Chlamydia trachomatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RCW FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15087448}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rcw OCA], [https://pdbe.org/1rcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rcw RCSB], [https://www.ebi.ac.uk/pdbsum/1rcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rcw ProSAT]</span></td></tr>
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[[1rcw]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Chlamydia_trachomatis Chlamydia trachomatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RCW OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CADD_CHLTR CADD_CHLTR] Involved in de novo para-aminobenzoate (PABA) biosynthesis (PubMed:23972426, PubMed:32967910, PubMed:36122239). Acts as a self-sacrificing or 'suicide' enzyme that utilizes its own active site tyrosine residue(s) as the substrate for PABA synthesis (PubMed:32967910, PubMed:36122239). The side chain of the tyrosine residue is released from the protein backbone via cleavage of the C(alpha)-C(beta) bond, leaving a glycine in place of the original tyrosine residue (PubMed:32967910, PubMed:36122239). Reaction requires O(2) and a reduced dimetal cofactor (PubMed:32967910, PubMed:36122239).<ref>PMID:23972426</ref> <ref>PMID:32967910</ref> <ref>PMID:36122239</ref> Was also identified as a specific toxin that associates with death domains of tumor necrosis factor family (TNF) receptors and induces apoptosis in mammalian cell lines through a Caspase-dependent mechanism.<ref>PMID:11805081</ref> <ref>PMID:15087448</ref>
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<ref group="xtra">PMID:015087448</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/1rcw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rcw ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Chlamydia trachomatis]]
[[Category: Chlamydia trachomatis]]
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[[Category: Liddington, R C.]]
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[[Category: Large Structures]]
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[[Category: Schwarzenbacher, R.]]
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[[Category: Liddington RC]]
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[[Category: Di-iron]]
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[[Category: Schwarzenbacher R]]
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[[Category: Iron]]
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[[Category: Metallo enzyme]]
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[[Category: Oxidoreductase]]
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[[Category: Redox enzyme]]
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[[Category: Toxin]]
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Current revision

Crystal structure of CT610 from Chlamydia trachomatis

PDB ID 1rcw

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