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1rmj

From Proteopedia

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[[Image:1rmj.png|left|200px]]
 
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==C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II==
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The line below this paragraph, containing "STRUCTURE_1rmj", creates the "Structure Box" on the page.
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<StructureSection load='1rmj' size='340' side='right'caption='[[1rmj]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rmj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RMJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rmj OCA], [https://pdbe.org/1rmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rmj RCSB], [https://www.ebi.ac.uk/pdbsum/1rmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rmj ProSAT]</span></td></tr>
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{{STRUCTURE_1rmj| PDB=1rmj | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IBP6_HUMAN IBP6_HUMAN] IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/1rmj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rmj ConSurf].
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<div style="clear:both"></div>
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===C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II===
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==See Also==
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*[[Insulin-like growth factor binding protein 3D structures|Insulin-like growth factor binding protein 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15308688}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15308688 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_15308688}}
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==About this Structure==
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[[1rmj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RMJ OCA].
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==Reference==
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<ref group="xtra">PMID:15308688</ref><ref group="xtra">PMID:15196913</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bach, L A.]]
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[[Category: Large Structures]]
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[[Category: Brasier, G.]]
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[[Category: Bach LA]]
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[[Category: Headey, S J.]]
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[[Category: Brasier G]]
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[[Category: Kantharidis, P.]]
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[[Category: Headey SJ]]
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[[Category: Keizer, D W.]]
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[[Category: Kantharidis P]]
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[[Category: Norton, R S.]]
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[[Category: Keizer DW]]
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[[Category: Yao, S.]]
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[[Category: Norton RS]]
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[[Category: Hormone/growth factor complex]]
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[[Category: Yao S]]
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[[Category: Insulin-like growth factor binding protein]]
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Current revision

C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II

PDB ID 1rmj

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