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1rre

From Proteopedia

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{{Seed}}
 
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[[Image:1rre.png|left|200px]]
 
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<!--
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==Crystal structure of E.coli Lon proteolytic domain==
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The line below this paragraph, containing "STRUCTURE_1rre", creates the "Structure Box" on the page.
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<StructureSection load='1rre' size='340' side='right'caption='[[1rre]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1rre]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RRE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1rre| PDB=1rre | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rre OCA], [https://pdbe.org/1rre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rre RCSB], [https://www.ebi.ac.uk/pdbsum/1rre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rre ProSAT]</span></td></tr>
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</table>
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===Crystal structure of E.coli Lon proteolytic domain===
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== Function ==
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[https://www.uniprot.org/uniprot/LON_ECOLI LON_ECOLI] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.<ref>PMID:12135363</ref> <ref>PMID:16584195</ref> <ref>PMID:19721064</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_14665623}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 14665623 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rr/1rre_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_14665623}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1RRE is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RRE OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rre ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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<ref group="xtra">PMID:14665623</ref><references group="xtra"/>
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<references/>
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[[Category: Endopeptidase La]]
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Botos, I.]]
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[[Category: Large Structures]]
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[[Category: Cherry, S.]]
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[[Category: Botos I]]
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[[Category: Dauter, Z.]]
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[[Category: Cherry S]]
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[[Category: Gustchina, A.]]
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[[Category: Dauter Z]]
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[[Category: Khalatova, A G.]]
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[[Category: Gustchina A]]
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[[Category: Maurizi, M R.]]
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[[Category: Khalatova AG]]
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[[Category: Melnikov, E E.]]
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[[Category: Maurizi MR]]
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[[Category: Rasulova, F.]]
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[[Category: Melnikov EE]]
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[[Category: Rotanova, T V.]]
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[[Category: Rasulova F]]
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[[Category: Tropea, J E.]]
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[[Category: Rotanova TV]]
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[[Category: Wlodawer, A.]]
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[[Category: Tropea JE]]
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[[Category: Atp-dependent protease]]
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[[Category: Wlodawer A]]
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[[Category: Catalytic ser-lys dyad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 08:51:13 2009''
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Current revision

Crystal structure of E.coli Lon proteolytic domain

PDB ID 1rre

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