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1ruv

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(New page: 200px<br /> <applet load="1ruv" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ruv, resolution 1.25&Aring;" /> '''RIBONUCLEASE A-URID...)
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[[Image:1ruv.gif|left|200px]]<br />
 
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<applet load="1ruv" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1ruv, resolution 1.25&Aring;" />
 
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'''RIBONUCLEASE A-URIDINE VANADATE COMPLEX: HIGH RESOLUTION RESOLUTION X-RAY STRUCTURE (1.3 A)'''<br />
 
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==Overview==
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==RIBONUCLEASE A-URIDINE VANADATE COMPLEX: HIGH RESOLUTION RESOLUTION X-RAY STRUCTURE (1.3 A)==
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The X-ray crystal structure of a uridine vanadate-ribonuclease A complex, has been determined at 1.3 A resolution. The resulting structure includes, all 124 amino-acid residues, a uridine vanadate, 131 water molecules, and, a single bound 2-methyl-2-propanol. Side chains of 11 surface residues, showing discrete disorder were modeled with multiple conformations. The, final crystallographic R factor is 0.197. Structures obtained from, high-level ab initio quantum calculations of model anionic oxyvanadate, compounds were used to probe the effects of starting structure on the, refinement process and final structure of the penta-coordinate phosphorane, analog, uridine vanadate. The least-squares refinement procedure gave rise, to the same final structure of the inhibitor despite significantly, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?15299932 (full description)]]
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<StructureSection load='1ruv' size='340' side='right'caption='[[1ruv]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1ruv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RUV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RUV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TBU:TERTIARY-BUTYL+ALCOHOL'>TBU</scene>, <scene name='pdbligand=UVC:URIDINE-2,3-VANADATE'>UVC</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ruv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ruv OCA], [https://pdbe.org/1ruv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ruv RCSB], [https://www.ebi.ac.uk/pdbsum/1ruv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ruv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ru/1ruv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ruv ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1RUV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]] with UVC and TBU as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1RUV OCA]].
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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== References ==
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==Reference==
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<references/>
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X-ray structure of a ribonuclease A-uridine vanadate complex at 1.3 A resolution., Ladner JE, Wladkowski BD, Svensson LA, Sjolin L, Gilliland GL, Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):290-301. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15299932 15299932]
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__TOC__
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</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gilliland, G.L.]]
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[[Category: Gilliland GL]]
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[[Category: Ladner, J.E.]]
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[[Category: Ladner JE]]
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[[Category: Sjolin, L.]]
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[[Category: Sjolin L]]
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[[Category: Svensson, L.A.]]
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[[Category: Svensson LA]]
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[[Category: Wladkowski, B.]]
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[[Category: Wladkowski B]]
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[[Category: TBU]]
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[[Category: UVC]]
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[[Category: endoribonuclease]]
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[[Category: glycoprotein]]
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[[Category: hydrolase]]
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[[Category: nuclease]]
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[[Category: signal]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 20:58:14 2007''
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Current revision

RIBONUCLEASE A-URIDINE VANADATE COMPLEX: HIGH RESOLUTION RESOLUTION X-RAY STRUCTURE (1.3 A)

PDB ID 1ruv

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