1rzi

<StructureSection load='1rzi' size='340' side='right' caption='[[1rzi]], [[Resolution|resolution]] 2.90&Aring;' scene=''>

<table><tr><td colspan='2'>[[1rzi]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1RZI FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1rz7|1rz7]], [[1rz8|1rz8]], [[1rzf|1rzf]], [[1rzg|1rzg]], [[1rzj|1rzj]], [[1rzk|1rzk]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rzi OCA], [http://pdbe.org/1rzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1rzi RCSB], [http://www.ebi.ac.uk/pdbsum/1rzi PDBsum]</span></td></tr>

<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rzi_consurf.spt"</scriptWhenChecked>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds to the HIV-1 coreceptor is protected from humoral recognition by multiple layers of camouflage. Here we present sequence and genomic analyses for 12 antibodies that pierce these defenses and determine the crystal structures of 5. The data reveal mechanisms and atomic-level details for three unusual immune features: posttranslational mimicry of coreceptor by tyrosine sulfation of antibody, an alternative molecular mechanism controlling such sulfation, and highly selective V(H)-gene usage. When confronted by extraordinary viral defenses, the immune system unveils novel adaptive capabilities, with tyrosine sulfation enhancing the vocabulary of antigen recognition.

Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120.,Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267<ref>PMID:14981267</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1rzi" style="background-color:#fffaf0;"></div>

*[[Antibody|Antibody]]

[[Category: Human]]

[[Category: Choe, H]]

[[Category: Dimitrov, D S]]

[[Category: Farzan, M]]

[[Category: Hendrickson, W A]]

[[Category: Huang, C C]]

[[Category: Kwong, P D]]

[[Category: Majeed, S]]

[[Category: Moore, M J]]

[[Category: Phogat, S]]

[[Category: Robinson, J]]

[[Category: Sodroski, J]]

[[Category: Venturi, M]]

[[Category: Wyatt, R]]

[[Category: Zhang, M Y]]

[[Category: Vh-gene usage]]