1s48

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[[Image:1s48.png|left|200px]]
 
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{{STRUCTURE_1s48| PDB=1s48 | SCENE= }}
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==Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV==
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<StructureSection load='1s48' size='340' side='right'caption='[[1s48]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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===Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s48]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S48 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15070734}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s48 OCA], [https://pdbe.org/1s48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s48 RCSB], [https://www.ebi.ac.uk/pdbsum/1s48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s48 ProSAT]</span></td></tr>
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[[1s48]] is a 1 chain structure of [[RNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S48 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLG_BVDVN POLG_BVDVN] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (Probable).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> Uncleaved NS2-3 is required for production of infectious virus.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> NS4A is a cofactor for the NS3 protease activity (By similarity).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s4/1s48_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s48 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[RNA polymerase|RNA polymerase]]
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:015070734</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Bovine viral diarrhea virus 1]]
[[Category: Bovine viral diarrhea virus 1]]
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[[Category: Choi, K H.]]
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[[Category: Large Structures]]
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[[Category: Groarke, J M.]]
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[[Category: Choi KH]]
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[[Category: Kuhn, R J.]]
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[[Category: Groarke JM]]
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[[Category: Pevear, D C.]]
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[[Category: Kuhn RJ]]
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[[Category: Rossmann, M G.]]
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[[Category: Pevear DC]]
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[[Category: Smith, J L.]]
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[[Category: Rossmann MG]]
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[[Category: Young, D C.]]
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[[Category: Smith JL]]
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[[Category: Bovine viral diarrhea virus]]
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[[Category: Young DC]]
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[[Category: Bvdv]]
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[[Category: De novo initiation]]
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[[Category: Polymerase]]
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[[Category: Primer independent initiation]]
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[[Category: Replication]]
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[[Category: Rna binding protein]]
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[[Category: Rna virus]]
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Current revision

Crystal structure of RNA-dependent RNA polymerase construct 1 (residues 71-679) from BVDV

PDB ID 1s48

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OCA

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