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1s5l

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(New page: 200px<br /> <applet load="1s5l" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s5l, resolution 3.5&Aring;" /> '''Architecture of the ...)
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[[Image:1s5l.gif|left|200px]]<br />
 
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<applet load="1s5l" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1s5l, resolution 3.5&Aring;" />
 
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'''Architecture of the photosynthetic oxygen evolving center'''<br />
 
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==Overview==
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==Architecture of the photosynthetic oxygen evolving center==
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Photosynthesis uses light energy to drive the oxidation of water at an, oxygen-evolving catalytic site within photosystem II (PSII). We report the, structure of PSII of the cyanobacterium Thermosynechococcus elongatus at, 3.5 angstrom resolution. We have assigned most of the amino acid residues, of this 650-kilodalton dimeric multisubunit complex and refined the, structure to reveal its molecular architecture. Consequently, we are able, to describe details of the binding sites for cofactors and propose a, structure of the oxygen-evolving center (OEC). The data strongly suggest, that the OEC contains a cubane-like Mn3CaO4 cluster linked to a fourth Mn, by a mono-micro-oxo bridge. The details of the surrounding coordination, sphere of the metal cluster and the implications for a possible, oxygen-evolving mechanism are discussed.
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<StructureSection load='1s5l' size='340' side='right'caption='[[1s5l]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s5l]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosynechococcus_vestitus Thermosynechococcus vestitus]. The November 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Photosystem II'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_11 10.2210/rcsb_pdb/mom_2004_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S5L FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCR:BETA-CAROTENE'>BCR</scene>, <scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CLA:CHLOROPHYLL+A'>CLA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=OEC:OXYGEN+EVOLVING+SYSTEM'>OEC</scene>, <scene name='pdbligand=PHO:PHEOPHYTIN+A'>PHO</scene>, <scene name='pdbligand=PL9:2,3-DIMETHYL-5-(3,7,11,15,19,23,27,31,35-NONAMETHYL-2,6,10,14,18,22,26,30,34-HEXATRIACONTANONAENYL-2,5-CYCLOHEXADIENE-1,4-DIONE-2,3-DIMETHYL-5-SOLANESYL-1,4-BENZOQUINONE'>PL9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s5l OCA], [https://pdbe.org/1s5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s5l RCSB], [https://www.ebi.ac.uk/pdbsum/1s5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s5l ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PSBA1_THEVB PSBA1_THEVB] Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.[HAMAP-Rule:MF_01379]<ref>PMID:20558739</ref> <ref>PMID:21367867</ref> <ref>PMID:25006873</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s5/1s5l_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s5l ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1S5L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Thermosynechococcus_elongatus Thermosynechococcus elongatus] with FE, BCT, OEC, CL1, PHO, HEM, PL9, LMT and BCR as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1S5L with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb59_1.html Photosystem II]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1S5L OCA].
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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==Reference==
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*[[Photosystem II|Photosystem II]]
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Architecture of the photosynthetic oxygen-evolving center., Ferreira KN, Iverson TM, Maghlaoui K, Barber J, Iwata S, Science. 2004 Mar 19;303(5665):1831-8. Epub 2004 Feb 5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=14764885 14764885]
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*[[Photosystem II 3D structures|Photosystem II 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Photosystem II]]
[[Category: Photosystem II]]
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[[Category: Protein complex]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Thermosynechococcus elongatus]]
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[[Category: Thermosynechococcus vestitus]]
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[[Category: Barber, J.]]
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[[Category: Barber J]]
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[[Category: Ferreira, K.N.]]
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[[Category: Ferreira KN]]
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[[Category: Iverson, T.M.]]
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[[Category: Iverson TM]]
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[[Category: Iwata, S.]]
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[[Category: Iwata S]]
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[[Category: Maghlaoui, K.]]
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[[Category: Maghlaoui K]]
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[[Category: BCR]]
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[[Category: BCT]]
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[[Category: CL1]]
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[[Category: FE]]
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[[Category: HEM]]
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[[Category: LMT]]
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[[Category: OEC]]
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[[Category: PHO]]
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[[Category: PL9]]
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[[Category: membrane]]
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[[Category: oxygen-evolving]]
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[[Category: photosynthesis]]
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[[Category: photosystem]]
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[[Category: tetra-manganese]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:05:54 2007''
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Current revision

Architecture of the photosynthetic oxygen evolving center

PDB ID 1s5l

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