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1sac

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[[Image:1sac.gif|left|200px]]<br /><applet load="1sac" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1sac, resolution 2.0&Aring;" />
 
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'''THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT'''<br />
 
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==Overview==
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==THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT==
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The three-dimensional structure of pentameric human serum amyloid P component at high resolution, the first reported for a pentraxin, reveals that the tertiary fold is remarkably similar to that of the legume lectins. Carboxylate and phosphate compounds bind directly to two calcium ions; interactions with a carboxyethylidene ring are mediated by Asn 59 and Gln 148 ligands of the calcium ions. These X-ray results indicate the probable modes of binding of the biologically important ligands, DNA and amyloid fibrils.
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<StructureSection load='1sac' size='340' side='right'caption='[[1sac]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sac]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SAC FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sac OCA], [https://pdbe.org/1sac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sac RCSB], [https://www.ebi.ac.uk/pdbsum/1sac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sac ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN] Note=SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits.
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== Function ==
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[https://www.uniprot.org/uniprot/SAMP_HUMAN SAMP_HUMAN] Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sa/1sac_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sac ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known disease associated with this structure: Amyloidosis, secondary, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=104770 104770]]
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*[[Serum amyloid P-component|Serum amyloid P-component]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1SAC is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SAC OCA].
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==Reference==
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Structure of pentameric human serum amyloid P component., Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP, Nature. 1994 Jan 27;367(6461):338-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8114934 8114934]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Blundell, T L.]]
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[[Category: Blundell TL]]
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[[Category: Emsley, J.]]
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[[Category: Emsley J]]
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[[Category: Hara, B P.O.]]
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[[Category: O'Hara BP]]
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[[Category: Oliva, G.]]
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[[Category: Oliva G]]
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[[Category: Pepys, M B.]]
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[[Category: Pepys MB]]
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[[Category: Srinivasan, N.]]
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[[Category: Srinivasan N]]
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[[Category: Tickle, I J.]]
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[[Category: Tickle IJ]]
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[[Category: White, H E.]]
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[[Category: White HE]]
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[[Category: Wood, S P.]]
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[[Category: Wood SP]]
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[[Category: ACY]]
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[[Category: CA]]
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[[Category: amyloid protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:59:27 2008''
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Current revision

THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT

PDB ID 1sac

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