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1se4

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STAPHYLOCOCCAL ENTEROTOXIN B COMPLEXED WITH LACTOSE

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Retrieved from "http://52.214.119.220/wiki/index.php/1se4"

Categories: Large Structures | Staphylococcus aureus | Sax M | Swaminathan S

@@ Line 1: / Line 1: @@
-[[Image:1se4.gif|left|200px]]
- {{Structure
+==STAPHYLOCOCCAL ENTEROTOXIN B COMPLEXED WITH LACTOSE==
-|PDB= 1se4 |SIZE=350|CAPTION= <scene name='initialview01'>1se4</scene>, resolution 1.9&Aring;
+<StructureSection load='1se4' size='340' side='right'caption='[[1se4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-|SITE= <scene name='pdbsite=LAC:Lactose+Binding+Site'>LAC</scene>
+== Structural highlights ==
-|LIGAND= <scene name='pdbligand=LAT:LACTOSE'>LAT</scene>
+<table><tr><td colspan='2'>[[1se4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SE4 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-|GENE=
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
-|DOMAIN=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1se4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1se4 OCA], [https://pdbe.org/1se4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1se4 RCSB], [https://www.ebi.ac.uk/pdbsum/1se4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1se4 ProSAT]</span></td></tr>
-|RELATEDENTRY=
+</table>
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1se4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1se4 OCA], [http://www.ebi.ac.uk/pdbsum/1se4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1se4 RCSB]</span>
+== Function ==
-}}
+[https://www.uniprot.org/uniprot/ETXB_STAAU ETXB_STAAU] Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.
+== Evolutionary Conservation ==
-'''STAPHYLOCOCCAL ENTEROTOXIN B COMPLEXED WITH LACTOSE'''
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
-==Overview==
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/se/1se4_consurf.spt"</scriptWhenChecked>
-The three-dimensional structure of staphylococcal enterotoxin C2 has been determined at 2.7 A resolution by x-ray diffraction, while the structures of enterotoxins A and E have been modelled based on their sequence homology to other staphylococcal enterotoxins. The T-cell receptor-binding sites of staphylococcal enterotoxin (SE) B and SEC2 are compared and the stereochemical interactions likely to be responsible for their differing V beta specificities are identified. A similar comparison is made between SEA and SEE.
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-SE4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SE4 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1se4 ConSurf].
+<div style="clear:both"></div>
-==Reference==
+__TOC__
-Residues defining V beta specificity in staphylococcal enterotoxins., Swaminathan S, Furey W, Pletcher J, Sax M, Nat Struct Biol. 1995 Aug;2(8):680-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7552730 7552730]
+</StructureSection>
-[[Category: Single protein]]
+[[Category: Large Structures]]
 [[Category: Staphylococcus aureus]]
-[[Category: Sax, M.]]
+[[Category: Sax M]]
-[[Category: Swaminathan, S.]]
+[[Category: Swaminathan S]]
-[[Category: 3d structure]]
-[[Category: complex]]
-[[Category: lactose]]
-[[Category: seb]]
-[[Category: superantigen]]
-[[Category: toxin]]
-[[Category: x-ray]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:40:49 2008''

1se4

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STAPHYLOCOCCAL ENTEROTOXIN B COMPLEXED WITH LACTOSE

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