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1shc

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(New page: 200px<br /> <applet load="1shc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1shc" /> '''SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPT...)
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[[Image:1shc.gif|left|200px]]<br />
 
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<applet load="1shc" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1shc" />
 
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'''SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE'''<br />
 
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==Overview==
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==SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE==
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The nuclear magnetic resonance structure of the phosphotyrosine binding, (PTB) domain of Shc complexed to a phosphopeptide reveals an alternative, means of recognizing tyrosine-phosphorylated proteins. Unlike in SH2, domains, the phosphopeptide forms an antiparallel beta-strand with a, beta-sheet of the protein, interacts with a hydrophobic pocket through the, (pY-5) residue, and adopts a beta-turn. The PTB domain is structurally, similar to pleckstrin homology domains (a beta-sandwich capped by an, alpha-helix) and binds to acidic phospholipids, suggesting a possible role, in membrane localization.
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<StructureSection load='1shc' size='340' side='right'caption='[[1shc]]' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1shc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SHC FirstGlance]. <br>
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Known diseases associated with this structure: Insensitivity to pain, congenital, with anhidrosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191315 191315]], Medullary thyroid carcinoma, familial OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191315 191315]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1shc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1shc OCA], [https://pdbe.org/1shc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1shc RCSB], [https://www.ebi.ac.uk/pdbsum/1shc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1shc ProSAT]</span></td></tr>
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1SHC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SHC OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/SHC1_HUMAN SHC1_HUMAN] Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.<ref>PMID:14665640</ref>
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Structure and ligand recognition of the phosphotyrosine binding domain of Shc., Zhou MM, Ravichandran KS, Olejniczak EF, Petros AM, Meadows RP, Sattler M, Harlan JE, Wade WS, Burakoff SJ, Fesik SW, Nature. 1995 Dec 7;378(6557):584-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8524391 8524391]
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== Evolutionary Conservation ==
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[[Category: Escherichia coli]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Protein complex]]
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Check<jmol>
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[[Category: Burakoff, S.J.]]
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<jmolCheckbox>
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[[Category: Fesik, S.W.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sh/1shc_consurf.spt"</scriptWhenChecked>
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[[Category: Harlan, J.E.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Meadows, R.P.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Olejniczak, E.T.]]
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</jmolCheckbox>
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[[Category: Petros, A.M.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1shc ConSurf].
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[[Category: Ravichandran, K.S.]]
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<div style="clear:both"></div>
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[[Category: Sattler, M.]]
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== References ==
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[[Category: Wade, W.S.]]
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<references/>
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[[Category: Zhou, M.M.]]
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__TOC__
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[[Category: complex (signal transduction/peptide)]]
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</StructureSection>
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[[Category: phosphotyrosine binding domain (ptb)]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:13:34 2007''
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[[Category: Burakoff SJ]]
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[[Category: Fesik SW]]
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[[Category: Harlan JE]]
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[[Category: Meadows RP]]
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[[Category: Olejniczak ET]]
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[[Category: Petros AM]]
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[[Category: Ravichandran KS]]
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[[Category: Sattler M]]
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[[Category: Wade WS]]
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[[Category: Zhou M-M]]

Current revision

SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE

PDB ID 1shc

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