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1sl6

From Proteopedia

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[[Image:1sl6.png|left|200px]]
 
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{{STRUCTURE_1sl6| PDB=1sl6 | SCENE= }}
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==Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.==
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<StructureSection load='1sl6' size='340' side='right'caption='[[1sl6]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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===Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sl6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SL6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_15195147}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PRD_900120:Lewis+X+antigen,+alpha+anomer'>PRD_900120</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sl6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sl6 OCA], [https://pdbe.org/1sl6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sl6 RCSB], [https://www.ebi.ac.uk/pdbsum/1sl6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sl6 ProSAT]</span></td></tr>
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[[1sl6]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SL6 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/CLC4M_HUMAN CLC4M_HUMAN] Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus.<ref>PMID:11257134</ref> <ref>PMID:11226297</ref>
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<ref group="xtra">PMID:015195147</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sl/1sl6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sl6 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Alvarez, R.]]
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[[Category: Large Structures]]
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[[Category: Blixt, O.]]
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[[Category: Alvarez R]]
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[[Category: Conroy, E.]]
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[[Category: Blixt O]]
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[[Category: Drickamer, K.]]
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[[Category: Conroy E]]
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[[Category: Feinberg, H.]]
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[[Category: Drickamer K]]
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[[Category: Guo, Y.]]
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[[Category: Feinberg H]]
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[[Category: Mitchell, D A.]]
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[[Category: Guo Y]]
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[[Category: Taylor, M E.]]
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[[Category: Mitchell DA]]
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[[Category: Weis, W I.]]
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[[Category: Taylor ME]]
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[[Category: C-type lectin]]
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[[Category: Weis WI]]
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[[Category: Dc-signr]]
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[[Category: Sugar binding protein]]
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Current revision

Crystal Structure of a fragment of DC-SIGNR (containg the carbohydrate recognition domain and two repeats of the neck) complexed with Lewis-x.

PDB ID 1sl6

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OCA

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