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1smr

From Proteopedia

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{{Seed}}
 
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[[Image:1smr.png|left|200px]]
 
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==The 3-d structure of mouse submaxillary renin complexed with a decapeptide inhibitor ch-66 based on the 4-16 fragment of rat angiotensinogen==
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The line below this paragraph, containing "STRUCTURE_1smr", creates the "Structure Box" on the page.
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<StructureSection load='1smr' size='340' side='right'caption='[[1smr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1smr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SMR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LPL:LEU-HYDROXYETHYLENE-LEU'>LPL</scene>, <scene name='pdbligand=PIV:PIVALIC+ACID'>PIV</scene></td></tr>
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{{STRUCTURE_1smr| PDB=1smr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1smr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1smr OCA], [https://pdbe.org/1smr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1smr RCSB], [https://www.ebi.ac.uk/pdbsum/1smr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1smr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RENI2_MOUSE RENI2_MOUSE] Renin is a highly specific endopeptidase, related to pepsin, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Its function in the salivary gland is not understood.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sm/1smr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1smr ConSurf].
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<div style="clear:both"></div>
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===THE 3-D STRUCTURE OF MOUSE SUBMAXILLARY RENIN COMPLEXED WITH A DECAPEPTIDE INHIBITOR CH-66 BASED ON THE 4-16 FRAGMENT OF RAT ANGIOTENSINOGEN===
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==See Also==
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*[[Renin|Renin]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8107115 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8107115}}
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==About this Structure==
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1SMR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SMR OCA].
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==Reference==
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X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen., Dealwis CG, Frazao C, Badasso M, Cooper JB, Tickle IJ, Driessen H, Blundell TL, Murakami K, Miyazaki H, Sueiras-Diaz J, et al., J Mol Biol. 1994 Feb 11;236(1):342-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8107115 8107115]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Renin]]
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[[Category: Blundell TL]]
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[[Category: Single protein]]
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[[Category: Dealwis CG]]
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[[Category: Blundell, T L.]]
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[[Category: Dealwis, C G.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:08:26 2008''
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Current revision

The 3-d structure of mouse submaxillary renin complexed with a decapeptide inhibitor ch-66 based on the 4-16 fragment of rat angiotensinogen

PDB ID 1smr

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