This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1sny

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:33, 1 May 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1sny.gif|left|200px]]
 
-
{{Structure
+
==Carbonyl reductase Sniffer of D. melanogaster==
-
|PDB= 1sny |SIZE=350|CAPTION= <scene name='initialview01'>1sny</scene>, resolution 1.75&Aring;
+
<StructureSection load='1sny' size='340' side='right'caption='[[1sny]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=NAP:NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE'>NAP</scene>
+
<table><tr><td colspan='2'>[[1sny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SNY FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
-
|GENE= sniffer ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sny OCA], [https://pdbe.org/1sny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sny RCSB], [https://www.ebi.ac.uk/pdbsum/1sny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sny ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Carbonyl reductase Sniffer of D. melanogaster'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/Q9W3H4_DROME Q9W3H4_DROME]
-
 
+
== Evolutionary Conservation ==
-
==Overview==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
In vivo studies with the fruit-fly Drosophila melanogaster have shown that the Sniffer protein prevents age-dependent and oxidative stress-induced neurodegenerative processes. Sniffer is a NADPH-dependent carbonyl reductase belonging to the enzyme family of short-chain dehydrogenases/reductases (SDRs). The crystal structure of the homodimeric Sniffer protein from Drosophila melanogaster in complex with NADP+ has been determined by multiple-wavelength anomalous dispersion and refined to a resolution of 1.75 A. The observed fold represents a typical dinucleotide-binding domain as detected for other SDRs. With respect to the cofactor-binding site and the region referred to as substrate-binding loop, the Sniffer protein shows a striking similarity to the porcine carbonyl reductase (PTCR). This loop, in both Sniffer and PTCR, is substantially shortened compared to other SDRs. In most enzymes of the SDR family this loop adopts a well-defined conformation only after substrate binding and remains disordered in the absence of any bound ligands or even if only the dinucleotide cofactor is bound. In the structure of the Sniffer protein, however, the conformation of this loop is well defined, although no substrate is present. Molecular modeling studies provide an idea of how binding of substrate molecules to Sniffer could possibly occur.
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sn/1sny_consurf.spt"</scriptWhenChecked>
-
1SNY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNY OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==Reference==
+
</jmolCheckbox>
-
Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster., Sgraja T, Ulschmid J, Becker K, Schneuwly S, Klebe G, Reuter K, Heine A, J Mol Biol. 2004 Oct 1;342(5):1613-24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15364585 15364585]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sny ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Becker, K.]]
+
[[Category: Becker K]]
-
[[Category: Heine, A.]]
+
[[Category: Heine A]]
-
[[Category: Klebe, G.]]
+
[[Category: Klebe G]]
-
[[Category: Reuter, K.]]
+
[[Category: Reuter K]]
-
[[Category: Schneuwly, S.]]
+
[[Category: Schneuwly S]]
-
[[Category: Sgraja, T.]]
+
[[Category: Sgraja T]]
-
[[Category: Ulschmid, J.]]
+
[[Category: Ulschmid J]]
-
[[Category: NAP]]
+
-
[[Category: alpha and beta protein]]
+
-
[[Category: dinucleotide binding motif]]
+
-
[[Category: rossmann fold]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:07:34 2008''
+

Current revision

Carbonyl reductase Sniffer of D. melanogaster

PDB ID 1sny

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1sny"
Personal tools