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1spj

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{{Seed}}
 
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[[Image:1spj.png|left|200px]]
 
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==STRUCTURE OF MATURE HUMAN TISSUE KALLIKREIN (HUMAN KALLIKREIN 1 OR KLK1) AT 1.70 ANGSTROM RESOLUTION WITH VACANT ACTIVE SITE==
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The line below this paragraph, containing "STRUCTURE_1spj", creates the "Structure Box" on the page.
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<StructureSection load='1spj' size='340' side='right'caption='[[1spj]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1spj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SPJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1spj| PDB=1spj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1spj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1spj OCA], [https://pdbe.org/1spj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1spj RCSB], [https://www.ebi.ac.uk/pdbsum/1spj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1spj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KLK1_HUMAN KLK1_HUMAN] Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sp/1spj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1spj ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF MATURE HUMAN TISSUE KALLIKREIN (HUMAN KALLIKREIN 1 OR KLK1) AT 1.70 ANGSTROM RESOLUTION WITH VACANT ACTIVE SITE===
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==See Also==
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*[[Kallikrein 3D structures|Kallikrein 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15651049}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15651049 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15651049}}
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==Disease==
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Known disease associated with this structure: Kallikrein, decreased urinary activity of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147910 147910]]
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==About this Structure==
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1SPJ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPJ OCA].
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==Reference==
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<ref group="xtra">PMID:15651049</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Tissue kallikrein]]
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[[Category: Large Structures]]
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[[Category: Bernett, M J.]]
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[[Category: Bernett MJ]]
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[[Category: Blaber, M.]]
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[[Category: Blaber M]]
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[[Category: Blaber, S I.]]
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[[Category: Blaber SI]]
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[[Category: Laxmikanthan, G.]]
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[[Category: Laxmikanthan G]]
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[[Category: Hk1]]
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[[Category: Human kallikrein 1]]
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[[Category: Human tissue kallikrein 1]]
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[[Category: Klk1]]
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[[Category: Serine protease]]
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[[Category: Tissue kallikrein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 04:28:15 2009''
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Current revision

STRUCTURE OF MATURE HUMAN TISSUE KALLIKREIN (HUMAN KALLIKREIN 1 OR KLK1) AT 1.70 ANGSTROM RESOLUTION WITH VACANT ACTIVE SITE

PDB ID 1spj

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