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1sq6

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[[Image:1sq6.png|left|200px]]
 
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{{STRUCTURE_1sq6| PDB=1sq6 | SCENE= }}
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==Plasmodium falciparum homolog of Uridine phosphorylase/Purine nucleoside phosphorylase==
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<StructureSection load='1sq6' size='340' side='right'caption='[[1sq6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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===Plasmodium falciparum homolog of Uridine phosphorylase/Purine nucleoside phosphorylase===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1sq6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQ6 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16131758}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sq6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sq6 OCA], [https://pdbe.org/1sq6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sq6 RCSB], [https://www.ebi.ac.uk/pdbsum/1sq6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sq6 ProSAT]</span></td></tr>
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[[1sq6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQ6 OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/PNPH_PLAF7 PNPH_PLAF7] As part of the purine salvage pathway, catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:18957439, PubMed:14982926, PubMed:16131758, PubMed:19575810, PubMed:24416224, PubMed:29440412). Preferentially acts on inosine and guanosine, and to a lesser extent on 2'-deoxyguanosine and guanosine (PubMed:14982926, PubMed:16131758, PubMed:19575810). Also catalyzes the phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine; MTI is produced by adenosine deaminase (ADA)-mediated breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Generates hypoxanthine from both the purine salvage pathway and from polyamine metabolism which is required for nucleic acids synthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Has no activity towards adenosine (By similarity).[UniProtKB:Q8T9Z7]<ref>PMID:14982926</ref> <ref>PMID:16131758</ref> <ref>PMID:18957439</ref> <ref>PMID:19575810</ref> <ref>PMID:24416224</ref> <ref>PMID:29440412</ref>
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<ref group="xtra">PMID:016131758</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Plasmodium falciparum]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Uridine phosphorylase]]
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Check<jmol>
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[[Category: Hol, W G.J.]]
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<jmolCheckbox>
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[[Category: Robien, M A.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sq6_consurf.spt"</scriptWhenChecked>
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[[Category: SGPP, Structural Genomics of Pathogenic Protozoa Consortium.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Alpha+beta]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Protein structure initiative]]
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</jmolCheckbox>
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[[Category: Psi]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sq6 ConSurf].
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[[Category: Sgpp]]
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<div style="clear:both"></div>
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[[Category: Structural genomic]]
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== References ==
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[[Category: Structural genomics of pathogenic protozoa consortium]]
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<references/>
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[[Category: Transferase]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Hol WGJ]]
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[[Category: Robien MA]]

Current revision

Plasmodium falciparum homolog of Uridine phosphorylase/Purine nucleoside phosphorylase

PDB ID 1sq6

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