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1sqt

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[[Image:1sqt.jpg|left|200px]]
 
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{{Structure
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==Substituted 2-Naphthamidine Inhibitors of Urokinase==
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|PDB= 1sqt |SIZE=350|CAPTION= <scene name='initialview01'>1sqt</scene>, resolution 1.90&Aring;
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<StructureSection load='1sqt' size='340' side='right'caption='[[1sqt]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene>
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<table><tr><td colspan='2'>[[1sqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQT FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/U-plasminogen_activator U-plasminogen activator], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.73 3.4.21.73]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= PLAU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UI3:7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE'>UI3</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqt OCA], [https://pdbe.org/1sqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sqt RCSB], [https://www.ebi.ac.uk/pdbsum/1sqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sqt ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sqt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sqt ConSurf].
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<div style="clear:both"></div>
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'''Substituted 2-Naphthamidine Inhibitors of Urokinase'''
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==See Also==
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*[[Urokinase 3D Structures|Urokinase 3D Structures]]
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== References ==
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==Overview==
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<references/>
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Several 8-substituted 2-naphthamidine-based inhibitors of the serine protease urokinase plasminogen activator (uPA) are described. Direct attachment of five-membered saturated or unsaturated rings improved inhibitor performance; substitution with sulfones further improved binding profiles. Combination of these substituents or of previously described NH-linked heteroaromatic rings with 6-phenyl amide substituents provided further enhancements to potency and selectivity.
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__TOC__
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</StructureSection>
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==Disease==
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Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191840 191840]]
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==About this Structure==
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1SQT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQT OCA].
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==Reference==
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Interaction with the S1 beta-pocket of urokinase: 8-heterocycle substituted and 6,8-disubstituted 2-naphthamidine urokinase inhibitors., Wendt MD, Geyer A, McClellan WJ, Rockway TW, Weitzberg M, Zhao X, Mantei R, Stewart K, Nienaber V, Klinghofer V, Giranda VL, Bioorg Med Chem Lett. 2004 Jun 21;14(12):3063-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15149645 15149645]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: U-plasminogen activator]]
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[[Category: Geyer A]]
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[[Category: Geyer, A.]]
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[[Category: Giranda VL]]
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[[Category: Giranda, V L.]]
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[[Category: Klinghofer V]]
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[[Category: Klinghofer, V.]]
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[[Category: Mantei R]]
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[[Category: Mantei, R.]]
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[[Category: McClellan WJ]]
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[[Category: McClellan, W J.]]
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[[Category: Nienaber V]]
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[[Category: Nienaber, V.]]
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[[Category: Rockway TW]]
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[[Category: Rockway, T W.]]
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[[Category: Stewart K]]
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[[Category: Stewart, K.]]
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[[Category: Weitzberg M]]
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[[Category: Weitzberg, M.]]
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[[Category: Wendt MD]]
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[[Category: Wendt, M D.]]
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[[Category: Zhang X]]
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[[Category: Zhang, X.]]
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[[Category: UI3]]
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[[Category: egf-like domain]]
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[[Category: glycoprotein]]
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[[Category: hydrolase]]
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[[Category: kringle]]
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[[Category: plasminogen activation]]
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[[Category: serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 14:08:32 2008''
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Current revision

Substituted 2-Naphthamidine Inhibitors of Urokinase

PDB ID 1sqt

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