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1sqv

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[[Image:1sqv.gif|left|200px]]
 
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{{Structure
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==Crystal Structure Analysis of Bovine Bc1 with UHDBT==
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|PDB= 1sqv |SIZE=350|CAPTION= <scene name='initialview01'>1sqv</scene>, resolution 2.85&Aring;
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<StructureSection load='1sqv' size='340' side='right'caption='[[1sqv]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=UHD:6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE'>UHD</scene>, <scene name='pdbligand=UQ2:UBIQUINONE-2'>UQ2</scene>
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<table><tr><td colspan='2'>[[1sqv]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SQV FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=UHD:6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE'>UHD</scene>, <scene name='pdbligand=UQ2:UBIQUINONE-2'>UQ2</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqv OCA], [https://pdbe.org/1sqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sqv RCSB], [https://www.ebi.ac.uk/pdbsum/1sqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sqv ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1qcr|1QCR]], [[1lol|1LOL]], [[1sqp|1SQP]], [[1sqq|1SQQ]], [[1sqb|1SQB]], [[1sqx|1SQX]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sqv OCA], [http://www.ebi.ac.uk/pdbsum/1sqv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sqv RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/QCR1_BOVIN QCR1_BOVIN] This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sq/1sqv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sqv ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure Analysis of Bovine Bc1 with UHDBT'''
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==See Also==
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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*[[Cytochrome bc1 3D structures|Cytochrome bc1 3D structures]]
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==Overview==
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__TOC__
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Cytochrome bc(1) is an integral membrane protein complex essential for cellular respiration and photosynthesis; it couples electron transfer from quinol to cytochrome c to proton translocation across the membrane. Specific bc(1) inhibitors have not only played crucial roles in elucidating the mechanism of bc(1) function but have also provided leads for the development of novel antibiotics. Crystal structures of bovine bc(1) in complex with the specific Q(o) site inhibitors azoxystrobin, MOAS, myxothiazol, stigmatellin and 5-undecyl-6-hydroxy-4,7-dioxobenzothiazole were determined. Interactions, conformational changes and possible mechanisms of resistance, specific to each inhibitor, were defined. Residues and secondary structure elements that are capable of discriminating different classes of Q(o) site inhibitors were identified for the cytochrome b subunit. Directions in the displacement of the cd1 helix of cytochrome b subunit in response to various Q(o) site inhibitors were correlated to the binary conformational switch of the extrinsic domain of the iron-sulfur protein subunit. The new structural information, together with structures previously determined, provide a basis that, combined with biophysical and mutational data, suggest a modification to the existing classification of bc(1) inhibitors. bc(1) inhibitors are grouped into three classes: class P inhibitors bind to the Q(o) site, class N inhibitors bind to the Q(i) site and the class PN inhibitors target both sites. Class P contains two subgroups, Pm and Pf, that are distinct by their ability to induce mobile or fixed conformation of iron-sulfur protein.
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</StructureSection>
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==About this Structure==
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1SQV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SQV OCA].
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==Reference==
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Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex., Esser L, Quinn B, Li YF, Zhang M, Elberry M, Yu L, Yu CA, Xia D, J Mol Biol. 2004 Jul 30;341(1):281-302. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15312779 15312779]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Ubiquinol--cytochrome-c reductase]]
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[[Category: Elberry M]]
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[[Category: Elberry, M.]]
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[[Category: Esser L]]
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[[Category: Esser, L.]]
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[[Category: Li YF]]
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[[Category: Li, Y F.]]
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[[Category: Quinn B]]
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[[Category: Quinn, B.]]
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[[Category: Xia D]]
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[[Category: Xia, D.]]
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[[Category: Yu CA]]
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[[Category: Yu, C A.]]
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[[Category: Yu L]]
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[[Category: Yu, L.]]
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[[Category: Zhang M]]
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[[Category: Zhang, M.]]
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[[Category: cytochrome bc1]]
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[[Category: electron transport]]
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[[Category: membrane protein]]
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[[Category: qo inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:45:47 2008''
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Current revision

Crystal Structure Analysis of Bovine Bc1 with UHDBT

PDB ID 1sqv

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