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1ssu

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{{Seed}}
 
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[[Image:1ssu.png|left|200px]]
 
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==Structural and biochemical evidence for disulfide bond heterogeneity in active forms of the somatomedin B domain of human vitronectin==
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The line below this paragraph, containing "STRUCTURE_1ssu", creates the "Structure Box" on the page.
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<StructureSection load='1ssu' size='340' side='right'caption='[[1ssu]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ssu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SSU FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ssu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ssu OCA], [https://pdbe.org/1ssu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ssu RCSB], [https://www.ebi.ac.uk/pdbsum/1ssu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ssu ProSAT]</span></td></tr>
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{{STRUCTURE_1ssu| PDB=1ssu | SCENE= }}
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</table>
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== Function ==
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===Structural and biochemical evidence for disulfide bond heterogeneity in active forms of the somatomedin B domain of human vitronectin===
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[https://www.uniprot.org/uniprot/VTNC_HUMAN VTNC_HUMAN] Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_15157085}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 15157085 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ss/1ssu_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_15157085}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ssu ConSurf].
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1SSU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSU OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Disulfide bonding arrangements in active forms of the somatomedin B domain of human vitronectin., Kamikubo Y, De Guzman R, Kroon G, Curriden S, Neels JG, Churchill MJ, Dawson P, Oldziej S, Jagielska A, Scheraga HA, Loskutoff DJ, Dyson HJ, Biochemistry. 2004 Jun 1;43(21):6519-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15157085 15157085]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Churchill, M J.]]
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[[Category: Churchill MJ]]
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[[Category: Curriden, S.]]
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[[Category: Curriden S]]
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[[Category: Dawson, P.]]
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[[Category: Dawson P]]
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[[Category: Dyson, H J.]]
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[[Category: De Guzman R]]
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[[Category: Guzman, R De.]]
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[[Category: Dyson HJ]]
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[[Category: Jagielska, A.]]
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[[Category: Jagielska A]]
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[[Category: Kamikubo, Y.]]
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[[Category: Kamikubo Y]]
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[[Category: Kroon, G.]]
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[[Category: Kroon G]]
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[[Category: Loskutoff, D J.]]
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[[Category: Loskutoff DJ]]
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[[Category: Neels, J G.]]
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[[Category: Neels JG]]
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[[Category: Oldziej, S.]]
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[[Category: Oldziej S]]
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[[Category: Scheraga, H A.]]
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[[Category: Scheraga HA]]
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[[Category: Disulfide bonds heterogeneity]]
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[[Category: Nmr structure]]
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[[Category: Somatostatin b domain]]
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[[Category: Vitronectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:06:39 2008''
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Current revision

Structural and biochemical evidence for disulfide bond heterogeneity in active forms of the somatomedin B domain of human vitronectin

PDB ID 1ssu

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