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1t15

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{{Seed}}
 
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[[Image:1t15.png|left|200px]]
 
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==Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase==
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The line below this paragraph, containing "STRUCTURE_1t15", creates the "Structure Box" on the page.
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<StructureSection load='1t15' size='340' side='right'caption='[[1t15]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1t15]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T15 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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{{STRUCTURE_1t15| PDB=1t15 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t15 OCA], [https://pdbe.org/1t15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t15 RCSB], [https://www.ebi.ac.uk/pdbsum/1t15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t15 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FANCJ_HUMAN FANCJ_HUMAN] Defects in BRIP1 are a cause of susceptibility to breast cancer (BC) [MIM:[https://omim.org/entry/114480 114480]. A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.<ref>PMID:11301010</ref> <ref>PMID:14983014</ref> <ref>PMID:16153896</ref> <ref>PMID:16116421</ref> Defects in BRIP1 are the cause of Fanconi anemia complementation group J (FANCJ) [MIM:[https://omim.org/entry/609054 609054]. It is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.<ref>PMID:16153896</ref> <ref>PMID:16116421</ref> <ref>PMID:20639400</ref> <ref>PMID:16116424</ref> <ref>PMID:16116423</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FANCJ_HUMAN FANCJ_HUMAN] DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.<ref>PMID:11301010</ref> <ref>PMID:14983014</ref> <ref>PMID:16153896</ref> <ref>PMID:16116421</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t1/1t15_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t15 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase===
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==See Also==
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*[[BRCA 3D structures|BRCA 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15133502}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15133502 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15133502}}
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==Disease==
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Known disease associated with this structure: Breast cancer-1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705 113705]], Breast-ovarian cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705 113705]], Ovarian cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705 113705]], Papillary serous carcinoma of the peritoneum OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=113705 113705]]
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==About this Structure==
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1T15 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T15 OCA].
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==Reference==
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Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer., Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ, Nat Struct Mol Biol. 2004 Jun;11(6):512-8. Epub 2004 May 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15133502 15133502]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Clapperton, J A.]]
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[[Category: Clapperton JA]]
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[[Category: Haire, L F.]]
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[[Category: Haire LF]]
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[[Category: Ho, T.]]
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[[Category: Ho T]]
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[[Category: Lowery, D M.]]
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[[Category: Lowery DM]]
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[[Category: Manke, I A.]]
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[[Category: Manke IA]]
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[[Category: Smerdon, S J.]]
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[[Category: Smerdon SJ]]
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[[Category: Yaffe, M B.]]
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[[Category: Yaffe MB]]
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[[Category: Protein-peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:21:50 2008''
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Current revision

Crystal Structure of the Brca1 BRCT Domains in Complex with the Phosphorylated Interacting Region from Bach1 Helicase

PDB ID 1t15

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