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1t3g

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(New page: 200px<br /> <applet load="1t3g" size="450" color="white" frame="true" align="right" spinBox="true" caption="1t3g, resolution 2.30&Aring;" /> '''Crystal structure o...)
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[[Image:1t3g.gif|left|200px]]<br />
 
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<applet load="1t3g" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1t3g, resolution 2.30&Aring;" />
 
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'''Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL'''<br />
 
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==Overview==
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==Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL==
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The Toll/interleukin-1 receptor (TIR) domain is conserved in the, intracellular regions of Toll-like receptors (TLRs) and interleukin-1, receptors (IL-1Rs) as well as in several cytoplasmic adapter molecules., This domain has crucial roles in signal transduction by these receptors, for host immune response. Here we report the crystal structure at 2.3-A, resolution of the TIR domain of human IL-1RAPL, the first structure of a, TIR domain of the IL-1R superfamily. There are large structural, differences between this TIR domain and that of TLR1 and TLR2. Helix, alphaD in IL-1RAPL is almost perpendicular to its equivalent in TLR1 or, TLR2. The BB loop contains a hydrogen bond unique to IL-1RAPL between Thr, residues at the 8th and 10th positions. The structural and sequence, diversity among these domains may be important for specificity in the, signal transduction by these receptors. A dimer of the TIR domain of, IL-1RAPL is observed in the crystal, although this domain is monomeric in, solution. Residues in the dimer interface are mostly unique to IL-1RAPL, which is consistent with the distinct functional roles of this receptor., Our functional studies show IL-1RAPL can activate JNK but not the ERK or, the p38 MAP kinases, whereas its close homolog, TIGIRR, cannot activate, JNK. Deletion mutagenesis studies show that the activation of JNK by, IL-1RAPL does not depend on the integrity of its TIR domain, suggesting a, distinct mechanism of signaling through this receptor.
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<StructureSection load='1t3g' size='340' side='right'caption='[[1t3g]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[1t3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T3G FirstGlance]. <br>
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Known disease associated with this structure: Mental retardation, X-linked, 21/34 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300206 300206]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3g OCA], [https://pdbe.org/1t3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t3g RCSB], [https://www.ebi.ac.uk/pdbsum/1t3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t3g ProSAT]</span></td></tr>
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1T3G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1T3G OCA].
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</table>
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== Disease ==
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==Reference==
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[https://www.uniprot.org/uniprot/IRPL1_HUMAN IRPL1_HUMAN] Defects in IL1RAPL1 are the cause of mental retardation X-linked type 21 (MRX21) [MIM:[https://omim.org/entry/300143 300143]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.<ref>PMID:10757639</ref> <ref>PMID:16470793</ref>
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Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL., Khan JA, Brint EK, O'Neill LA, Tong L, J Biol Chem. 2004 Jul 23;279(30):31664-70. Epub 2004 Apr 30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15123616 15123616]
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== Function ==
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[https://www.uniprot.org/uniprot/IRPL1_HUMAN IRPL1_HUMAN] May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in presynaptic and postsynaptic differentiation and dendritic spine formation in neurons.<ref>PMID:12783849</ref> <ref>PMID:15123616</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t3/1t3g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t3g ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Khan, J.A.]]
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[[Category: Khan JA]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: il-1r]]
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[[Category: il-1rapl]]
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[[Category: tir]]
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[[Category: tlr]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:20:01 2007''
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Current revision

Crystal structure of the Toll/interleukin-1 receptor (TIR) domain of human IL-1RAPL

PDB ID 1t3g

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