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1t6e

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Crystal Structure of the Triticum aestivum xylanase inhibitor I

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Retrieved from "http://52.214.119.220/wiki/index.php/1t6e"

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-[[Image:1t6e.jpg|left|200px]]<br /><applet load="1t6e" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1t6e, resolution 1.70&Aring;" />
-'''Crystal Structure of the Triticum aestivum xylanase inhibitor I'''<br />
-==Overview==
+==Crystal Structure of the Triticum aestivum xylanase inhibitor I==
-Plants developed a diverse battery of defense mechanisms in response to, continual challenges by a broad spectrum of pathogenic microorganisms., Their defense arsenal includes inhibitors of cell wall-degrading enzymes, which hinder a possible invasion and colonization by antagonists. The, structure of Triticum aestivum xylanase inhibitor-I (TAXI-I), a first, member of potent TAXI-type inhibitors of fungal and bacterial family 11, xylanases, has been determined to 1.7-A resolution. Surprisingly, TAXI-I, displays structural homology with the pepsin-like family of aspartic, proteases but is proteolytically nonfunctional, because one or more, residues of the essential catalytical triad are absent. The structure of, the TAXI-I.Aspergillus niger xylanase I complex, at a resolution of 1.8 A, illustrates the ability of tight binding and inhibition with subnanomolar, affinity and indicates the importance of the C-terminal end for the, differences in xylanase specificity among different TAXI-type inhibitors.
+<StructureSection load='1t6e' size='340' side='right'caption='[[1t6e]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
+== Structural highlights ==
-==About this Structure==
+<table><tr><td colspan='2'>[[1t6e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T6E FirstGlance]. <br>
-T6E is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Triticum_aestivum Triticum aestivum] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Endo-1,4-beta-xylanase Endo-1,4-beta-xylanase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.8 3.2.1.8] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1T6E OCA].
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-==Reference==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t6e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t6e OCA], [https://pdbe.org/1t6e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t6e RCSB], [https://www.ebi.ac.uk/pdbsum/1t6e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t6e ProSAT]</span></td></tr>
-Structural basis for inhibition of Aspergillus niger xylanase by triticum aestivum xylanase inhibitor-I., Sansen S, De Ranter CJ, Gebruers K, Brijs K, Courtin CM, Delcour JA, Rabijns A, J Biol Chem. 2004 Aug 20;279(34):36022-8. Epub 2004 May 27. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15166216 15166216]
+</table>
-[[Category: Endo-1,4-beta-xylanase]]
+== Function ==
-[[Category: Single protein]]
+[https://www.uniprot.org/uniprot/Q8H0K8_WHEAT Q8H0K8_WHEAT]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t6/1t6e_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t6e ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Triticum aestivum]]
-[[Category: Brijs, K.]]
+[[Category: Brijs K]]
-[[Category: Courtin, C.M.]]
+[[Category: Courtin CM]]
-[[Category: Delcour, J.A.]]
+[[Category: De Ranter CJ]]
-[[Category: Gebruers, K.]]
+[[Category: Delcour JA]]
-[[Category: Rabijns, A.]]
+[[Category: Gebruers K]]
-[[Category: Ranter, C.J.De.]]
+[[Category: Rabijns A]]
-[[Category: Sansen, S.]]
+[[Category: Sansen S]]
-[[Category: GOL]]
-[[Category: two beta-barrel domain structure]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:44:46 2007''

1t6e

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Crystal Structure of the Triticum aestivum xylanase inhibitor I

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