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1t7s

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Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein

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Retrieved from "http://52.214.119.220/wiki/index.php/1t7s"

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-[[Image:1t7s.gif|left|200px]]<br /><applet load="1t7s" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1t7s, resolution 2.80&Aring;" />
-'''Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein'''<br />
-==Overview==
+==Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein==
-Binding of the BAG domain to the eukaryotic chaperone heat-shock protein, (Hsp70) promotes ATP-dependent release of the protein substrate from, Hsp70. Although the murine and human BAG domains have been shown to form, an antiparallel three-helix bundle, the Caenorhabditis elegans BAG domain, is formed by two antiparallel helices, while the third helix is extended, away and stabilized by crystal-packing interactions. A small beta-sheet, between helices 2 and 3 interferes with formation of the intramolecular, three-helix bundle. However, intermolecular three-helix bundles are, observed throughout the crystal packing and suggest that stable functional, dimers and tetramers can be formed in solution. The structure may, represent a new folding type of the BAG domain.
+<StructureSection load='1t7s' size='340' side='right'caption='[[1t7s]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1t7s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1T7S FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1t7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t7s OCA], [https://pdbe.org/1t7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1t7s RCSB], [https://www.ebi.ac.uk/pdbsum/1t7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1t7s ProSAT], [https://www.topsan.org/Proteins/SECSG/1t7s TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BAG1_CAEEL BAG1_CAEEL] May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/t7/1t7s_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1t7s ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-T7S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1T7S OCA].
+*[[BAG family proteins 3D structures|BAG family proteins 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Structural genomics of Caenorhabditis elegans: structure of the BAG domain., Symersky J, Zhang Y, Schormann N, Li S, Bunzel R, Pruett P, Luan CH, Luo M, Acta Crystallogr D Biol Crystallogr. 2004 Sep;60(Pt 9):1606-10. Epub 2004, Aug 26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15333932 15333932]
 [[Category: Caenorhabditis elegans]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Bunzel, R.]]
+[[Category: Bunzel R]]
-[[Category: Li, S.]]
+[[Category: Li S]]
-[[Category: Luan, C.H.]]
+[[Category: Luan C-H]]
-[[Category: Luo, M.]]
+[[Category: Luo M]]
-[[Category: Pruett, P.]]
+[[Category: Pruett P]]
-[[Category: SECSG, Southeast.Collaboratory.for.Structural.Genomics.]]
+[[Category: Schormann N]]
-[[Category: Schormann, N.]]
+[[Category: Symersky J]]
-[[Category: Symersky, J.]]
+[[Category: Zhang Y]]
-[[Category: Zhang, Y.]]
-[[Category: bag-1 cochaperone]]
-[[Category: protein structure initiative]]
-[[Category: psi]]
-[[Category: secsg]]
-[[Category: southeast collaboratory for structural genomics]]
-[[Category: structural genomics]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 03:03:23 2007''

1t7s

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Structural Genomics of Caenorhabditis elegans: Structure of BAG-1 protein

Structural highlights

Function

Evolutionary Conservation

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