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1tfs
From Proteopedia
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| - | [[Image:1tfs.png|left|200px]] | ||
| - | + | ==NMR AND RESTRAINED MOLECULAR DYNAMICS STUDY OF THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF TOXIN FS2, A SPECIFIC BLOCKER OF THE L-TYPE CALCIUM CHANNEL, ISOLATED FROM BLACK MAMBA VENOM== | |
| - | + | <StructureSection load='1tfs' size='340' side='right'caption='[[1tfs]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1tfs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TFS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tfs OCA], [https://pdbe.org/1tfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tfs RCSB], [https://www.ebi.ac.uk/pdbsum/1tfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tfs ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1tfs]] is a 1 chain structure with sequence from [ | + | == Function == |
| - | + | [https://www.uniprot.org/uniprot/3SL2_DENPO 3SL2_DENPO] Specific blocker of the voltage-dependent L-type calcium channel (Cav1/CACNA1) (PubMed:8826098). Inhibits cardiac contractions (By similarity).[UniProtKB:P22947]<ref>PMID:8826098</ref> | |
| - | == | + | == Evolutionary Conservation == |
| - | < | + | [[Image:Consurf_key_small.gif|200px|right]] |
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tfs_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tfs ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Dendroaspis polylepis polylepis]] | [[Category: Dendroaspis polylepis polylepis]] | ||
| - | [[Category: Albrand | + | [[Category: Large Structures]] |
| - | [[Category: Blackledge | + | [[Category: Albrand J-P]] |
| - | [[Category: Hollecker | + | [[Category: Blackledge MJ]] |
| - | [[Category: Marion | + | [[Category: Hollecker M]] |
| - | [[Category: Pascaud | + | [[Category: Marion D]] |
| - | + | [[Category: Pascaud F]] | |
Current revision
NMR AND RESTRAINED MOLECULAR DYNAMICS STUDY OF THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF TOXIN FS2, A SPECIFIC BLOCKER OF THE L-TYPE CALCIUM CHANNEL, ISOLATED FROM BLACK MAMBA VENOM
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