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1tfs

From Proteopedia

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{{Seed}}
 
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[[Image:1tfs.png|left|200px]]
 
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==NMR AND RESTRAINED MOLECULAR DYNAMICS STUDY OF THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF TOXIN FS2, A SPECIFIC BLOCKER OF THE L-TYPE CALCIUM CHANNEL, ISOLATED FROM BLACK MAMBA VENOM==
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The line below this paragraph, containing "STRUCTURE_1tfs", creates the "Structure Box" on the page.
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<StructureSection load='1tfs' size='340' side='right'caption='[[1tfs]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tfs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TFS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tfs OCA], [https://pdbe.org/1tfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tfs RCSB], [https://www.ebi.ac.uk/pdbsum/1tfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tfs ProSAT]</span></td></tr>
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{{STRUCTURE_1tfs| PDB=1tfs | SCENE= }}
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</table>
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== Function ==
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===NMR AND RESTRAINED MOLECULAR DYNAMICS STUDY OF THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF TOXIN FS2, A SPECIFIC BLOCKER OF THE L-TYPE CALCIUM CHANNEL, ISOLATED FROM BLACK MAMBA VENOM===
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[https://www.uniprot.org/uniprot/3SL2_DENPO 3SL2_DENPO] Specific blocker of the voltage-dependent L-type calcium channel (Cav1/CACNA1) (PubMed:8826098). Inhibits cardiac contractions (By similarity).[UniProtKB:P22947]<ref>PMID:8826098</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_7727450}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 7727450 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tf/1tfs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_7727450}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tfs ConSurf].
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1TFS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dendroaspis_polylepis_polylepis Dendroaspis polylepis polylepis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TFS OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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NMR and restrained molecular dynamics study of the three-dimensional solution structure of toxin FS2, a specific blocker of the L-type calcium channel, isolated from black mamba venom., Albrand JP, Blackledge MJ, Pascaud F, Hollecker M, Marion D, Biochemistry. 1995 May 2;34(17):5923-37. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7727450 7727450]
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__TOC__
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</StructureSection>
[[Category: Dendroaspis polylepis polylepis]]
[[Category: Dendroaspis polylepis polylepis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Albrand, J P.]]
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[[Category: Albrand J-P]]
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[[Category: Blackledge, M J.]]
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[[Category: Blackledge MJ]]
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[[Category: Hollecker, M.]]
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[[Category: Hollecker M]]
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[[Category: Marion, D.]]
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[[Category: Marion D]]
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[[Category: Pascaud, F.]]
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[[Category: Pascaud F]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:55:56 2008''
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Current revision

NMR AND RESTRAINED MOLECULAR DYNAMICS STUDY OF THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF TOXIN FS2, A SPECIFIC BLOCKER OF THE L-TYPE CALCIUM CHANNEL, ISOLATED FROM BLACK MAMBA VENOM

PDB ID 1tfs

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