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1tgr

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{{Seed}}
 
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[[Image:1tgr.png|left|200px]]
 
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==Crystal Structure of mini-IGF-1(2)==
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The line below this paragraph, containing "STRUCTURE_1tgr", creates the "Structure Box" on the page.
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<StructureSection load='1tgr' size='340' side='right'caption='[[1tgr]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tgr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TGR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.42&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tgr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgr OCA], [https://pdbe.org/1tgr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tgr RCSB], [https://www.ebi.ac.uk/pdbsum/1tgr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tgr ProSAT]</span></td></tr>
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{{STRUCTURE_1tgr| PDB=1tgr | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
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== Function ==
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[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tgr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tgr ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of mini-IGF-1(2)===
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==See Also==
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*[[Insulin-like growth factor|Insulin-like growth factor]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15567151 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15567151}}
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==About this Structure==
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1TGR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGR OCA].
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==Reference==
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1.42A crystal structure of mini-IGF-1(2): an analysis of the disulfide isomerization property and receptor binding property of IGF-1 based on the three-dimensional structure., Yun CH, Tang YH, Feng YM, An XM, Chang WR, Liang DC, Biochem Biophys Res Commun. 2005 Jan 7;326(1):52-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15567151 15567151]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Chang, W R.]]
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[[Category: Chang WR]]
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[[Category: Liang, D C.]]
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[[Category: Liang DC]]
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[[Category: Yun, C H.]]
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[[Category: Yun CH]]
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[[Category: Disulfide isomerization]]
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[[Category: Igf-1]]
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[[Category: Igf-i]]
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[[Category: Recepter binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:33:42 2008''
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Current revision

Crystal Structure of mini-IGF-1(2)

PDB ID 1tgr

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