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1tgx

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{{Seed}}
 
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[[Image:1tgx.png|left|200px]]
 
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==X-RAY STRUCTURE AT 1.55 A OF TOXIN GAMMA, A CARDIOTOXIN FROM NAJA NIGRICOLLIS VENOM. CRYSTAL PACKING REVEALS A MODEL FOR INSERTION INTO MEMBRANES==
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The line below this paragraph, containing "STRUCTURE_1tgx", creates the "Structure Box" on the page.
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<StructureSection load='1tgx' size='340' side='right'caption='[[1tgx]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tgx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TGX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_1tgx| PDB=1tgx | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tgx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tgx OCA], [https://pdbe.org/1tgx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tgx RCSB], [https://www.ebi.ac.uk/pdbsum/1tgx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tgx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/3SA1_NAJPA 3SA1_NAJPA] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity.[UniProtKB:P01443]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tg/1tgx_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tgx ConSurf].
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<div style="clear:both"></div>
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===X-RAY STRUCTURE AT 1.55 A OF TOXIN GAMMA, A CARDIOTOXIN FROM NAJA NIGRICOLLIS VENOM. CRYSTAL PACKING REVEALS A MODEL FOR INSERTION INTO MEMBRANES===
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==See Also==
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*[[Cardiotoxin 3D structures|Cardiotoxin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8196041}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8196041 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8196041}}
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==About this Structure==
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1TGX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_nigricollis Naja nigricollis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGX OCA].
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==Reference==
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X-ray structure at 1.55 A of toxin gamma, a cardiotoxin from Naja nigricollis venom. Crystal packing reveals a model for insertion into membranes., Bilwes A, Rees B, Moras D, Menez R, Menez A, J Mol Biol. 1994 May 27;239(1):122-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8196041 8196041]
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[[Category: Naja nigricollis]]
[[Category: Naja nigricollis]]
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[[Category: Single protein]]
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[[Category: Bilwes A]]
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[[Category: Bilwes, A.]]
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[[Category: Moras D]]
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[[Category: Moras, D.]]
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[[Category: Rees B]]
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[[Category: Rees, B.]]
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[[Category: Cytotoxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:44:33 2008''
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Current revision

X-RAY STRUCTURE AT 1.55 A OF TOXIN GAMMA, A CARDIOTOXIN FROM NAJA NIGRICOLLIS VENOM. CRYSTAL PACKING REVEALS A MODEL FOR INSERTION INTO MEMBRANES

PDB ID 1tgx

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