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1tiq

From Proteopedia

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[[Image:1tiq.png|left|200px]]
 
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{{STRUCTURE_1tiq| PDB=1tiq | SCENE= }}
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==Crystal Structure of an Acetyltransferase (PaiA) in complex with CoA and DTT from Bacillus subtilis, Northeast Structural Genomics Target SR64.==
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<StructureSection load='1tiq' size='340' side='right'caption='[[1tiq]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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===Crystal Structure of an Acetyltransferase (PaiA) in complex with CoA and DTT from Bacillus subtilis, Northeast Structural Genomics Target SR64.===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tiq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TIQ FirstGlance]. <br>
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{{ABSTRACT_PUBMED_16210326}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tiq OCA], [https://pdbe.org/1tiq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tiq RCSB], [https://www.ebi.ac.uk/pdbsum/1tiq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tiq ProSAT], [https://www.topsan.org/Proteins/NESGC/1tiq TOPSAN]</span></td></tr>
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[[1tiq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIQ OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/PAIA_BACSU PAIA_BACSU] Possesses N1-acetyltransferase activity toward polyamine substrates including spermidine and spermine. Can acetylate both spermidine and spermine. In this way it may function in regulating intracellular polyamine concentrations and/or binding capabilities. In addition to preventing toxicity due to polyamine excess, this function may also serve to regulate expression of certain bacterial gene products such as those involved in sporulation.<ref>PMID:16210326</ref>
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<ref group="xtra">PMID:016210326</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ti/1tiq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tiq ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Acton, T B.]]
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[[Category: Large Structures]]
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[[Category: Forouhar, F.]]
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[[Category: Acton TB]]
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[[Category: Hunt, J F.]]
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[[Category: Forouhar F]]
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[[Category: Lee, I.]]
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[[Category: Hunt JF]]
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[[Category: Montelione, G T.]]
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[[Category: Lee I]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Montelione GT]]
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[[Category: Shen, J.]]
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[[Category: Shen J]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Vorobiev, S M.]]
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[[Category: Vorobiev SM]]
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[[Category: Xiao, R.]]
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[[Category: Xiao R]]
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[[Category: Alpha-beta protein]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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[[Category: Transcription]]
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Current revision

Crystal Structure of an Acetyltransferase (PaiA) in complex with CoA and DTT from Bacillus subtilis, Northeast Structural Genomics Target SR64.

PDB ID 1tiq

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