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1tlc

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[[Image:1tlc.png|left|200px]]
 
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{{STRUCTURE_1tlc| PDB=1tlc | SCENE= }}
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==THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89==
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<StructureSection load='1tlc' size='340' side='right'caption='[[1tlc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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===THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tlc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TLC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_7724588}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGP:2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>DGP</scene>, <scene name='pdbligand=F89:S)-2-(5(((1,2-DIHYDRO-3-METHYL-1-OXOBENZO(F)QUINAZOLIN-9-YL)METHYL)AMINO)1-OXO-2-ISOINDOLINYL)GLUTARIC+ACID'>F89</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tlc OCA], [https://pdbe.org/1tlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tlc RCSB], [https://www.ebi.ac.uk/pdbsum/1tlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tlc ProSAT]</span></td></tr>
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[[1tlc]] is a 2 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TLC OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tl/1tlc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tlc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Thymidylate synthase|Thymidylate synthase]]
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*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:007724588</ref><ref group="xtra">PMID:011170211</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Thymidylate synthase]]
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[[Category: Large Structures]]
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[[Category: Ciesla, J.]]
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[[Category: Ciesla J]]
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[[Category: Maley, F.]]
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[[Category: Maley F]]
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[[Category: Montfort, W R.]]
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[[Category: Montfort WR]]
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[[Category: Weichsel, A.]]
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[[Category: Weichsel A]]
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[[Category: Methyltransferase]]
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Current revision

THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89

PDB ID 1tlc

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