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1tpn

From Proteopedia

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[[Image:1tpn.png|left|200px]]
 
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{{STRUCTURE_1tpn| PDB=1tpn | SCENE= }}
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==SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE==
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<StructureSection load='1tpn' size='340' side='right'caption='[[1tpn]]' scene=''>
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===SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TPN FirstGlance]. <br>
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{{ABSTRACT_PUBMED_1602484}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpn OCA], [https://pdbe.org/1tpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tpn RCSB], [https://www.ebi.ac.uk/pdbsum/1tpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tpn ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[1tpn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPN OCA].
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== Disease ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
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== Function ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/1tpn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tpn ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Plasminogen activator|Plasminogen activator]]
*[[Plasminogen activator|Plasminogen activator]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:001602484</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Baron, M.]]
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[[Category: Large Structures]]
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[[Category: Campbell, I D.]]
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[[Category: Baron M]]
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[[Category: Downing, A K.]]
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[[Category: Campbell ID]]
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[[Category: Driscoll, P C.]]
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[[Category: Downing AK]]
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[[Category: Dudgeon, T J.]]
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[[Category: Driscoll PC]]
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[[Category: Harvey, T S.]]
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[[Category: Dudgeon TJ]]
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[[Category: Smith, B O.]]
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[[Category: Harvey TS]]
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[[Category: Plasminogen activator]]
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[[Category: Smith BO]]

Current revision

SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE

PDB ID 1tpn

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