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1tpn

From Proteopedia

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{{Seed}}
 
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[[Image:1tpn.png|left|200px]]
 
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==SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE==
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The line below this paragraph, containing "STRUCTURE_1tpn", creates the "Structure Box" on the page.
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<StructureSection load='1tpn' size='340' side='right'caption='[[1tpn]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TPN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tpn OCA], [https://pdbe.org/1tpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tpn RCSB], [https://www.ebi.ac.uk/pdbsum/1tpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tpn ProSAT]</span></td></tr>
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{{STRUCTURE_1tpn| PDB=1tpn | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism.
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== Function ==
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[https://www.uniprot.org/uniprot/TPA_HUMAN TPA_HUMAN] Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tp/1tpn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tpn ConSurf].
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<div style="clear:both"></div>
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===SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE===
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==See Also==
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*[[Plasminogen activator|Plasminogen activator]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_1602484}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 1602484 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1602484}}
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==About this Structure==
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1TPN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TPN OCA].
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==Reference==
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Solution structure of the fibrin binding finger domain of tissue-type plasminogen activator determined by 1H nuclear magnetic resonance., Downing AK, Driscoll PC, Harvey TS, Dudgeon TJ, Smith BO, Baron M, Campbell ID, J Mol Biol. 1992 Jun 5;225(3):821-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1602484 1602484]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baron, M.]]
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[[Category: Baron M]]
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[[Category: Campbell, I D.]]
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[[Category: Campbell ID]]
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[[Category: Downing, A K.]]
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[[Category: Downing AK]]
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[[Category: Driscoll, P C.]]
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[[Category: Driscoll PC]]
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[[Category: Dudgeon, T J.]]
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[[Category: Dudgeon TJ]]
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[[Category: Harvey, T S.]]
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[[Category: Harvey TS]]
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[[Category: Smith, B O.]]
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[[Category: Smith BO]]
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[[Category: Plasminogen activator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:04:23 2008''
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Current revision

SOLUTION STRUCTURE OF THE FIBRIN BINDING FINGER DOMAIN OF TISSUE-TYPE PLASMINOGEN ACTIVATOR DETERMINED BY 1H NUCLEAR MAGNETIC RESONANCE

PDB ID 1tpn

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