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1tu4

From Proteopedia

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[[Image:1tu4.png|left|200px]]
 
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{{STRUCTURE_1tu4| PDB=1tu4 | SCENE= }}
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==Crystal Structure of Rab5-GDP Complex==
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<StructureSection load='1tu4' size='340' side='right'caption='[[1tu4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tu4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TU4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tu4 OCA], [https://pdbe.org/1tu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tu4 RCSB], [https://www.ebi.ac.uk/pdbsum/1tu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tu4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAB5A_HUMAN RAB5A_HUMAN] Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension.<ref>PMID:14978216</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tu/1tu4_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tu4 ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of Rab5-GDP Complex===
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==See Also==
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
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{{ABSTRACT_PUBMED_15378032}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1tu4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TU4 OCA].
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:015378032</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, G.]]
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[[Category: Large Structures]]
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[[Category: Liu, J.]]
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[[Category: Li G]]
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[[Category: Terzyan, S.]]
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[[Category: Liu J]]
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[[Category: Zhai, P.]]
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[[Category: Terzyan S]]
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[[Category: Zhang, X C.]]
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[[Category: Zhai P]]
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[[Category: Zhu, G.]]
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[[Category: Zhang XC]]
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[[Category: Gtpase]]
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[[Category: Zhu G]]
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[[Category: Protein transport]]
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[[Category: Rab5]]
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Current revision

Crystal Structure of Rab5-GDP Complex

PDB ID 1tu4

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