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1txa

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[[Image:1txa.jpg|left|200px]]
 
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==SOLUTION NMR STRUCTURE OF TOXIN B, A LONG NEUROTOXIN FROM THE VENOM OF THE KING COBRA, MINIMIZED AVERAGE STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1txa", creates the "Structure Box" on the page.
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<StructureSection load='1txa' size='340' side='right'caption='[[1txa]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1txa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TXA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1txa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1txa OCA], [https://pdbe.org/1txa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1txa RCSB], [https://www.ebi.ac.uk/pdbsum/1txa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1txa ProSAT]</span></td></tr>
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{{STRUCTURE_1txa| PDB=1txa | SCENE= }}
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</table>
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== Function ==
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'''SOLUTION NMR STRUCTURE OF TOXIN B, A LONG NEUROTOXIN FROM THE VENOM OF THE KING COBRA, MINIMIZED AVERAGE STRUCTURE'''
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[https://www.uniprot.org/uniprot/3L22_OPHHA 3L22_OPHHA] Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.[UniProtKB:P60615]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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The solution structure of toxin b, a long neurotoxin (73 amino acids and 5 disulfides) from the venom of Ophiophagus hannah (king cobra), has been determined using 1H NMR and dynamical simulated annealing techniques. The structures were calculated using 485 distance constraints and 52 dihedral angle restraints. The 21 structures that were obtained satisfy the experimental restraints and possess good nonbonded contacts. Analysis of the converged structures revealed that the protein consists of a core region from which three finger-like loops extend outwards. The regular secondary structure in toxin b includes a double and a triple stranded antiparallel beta sheet. Comparison with the solution structures of other long neurotoxins reveals that although the structure of toxin b is similar to those of previously reported long neurotoxins, clear local structural differences are observed in regions proposed to be involved in binding to the acetylcholine receptor. A positively charged cluster is found in the C-terminal tail, in Loop III, and in the tip of Loop II. This cationic cluster could be crucial for the binding of the long neurotoxins to the acetylcholine receptor.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tx/1txa_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1TXA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TXA OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1txa ConSurf].
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Solution structure of toxin b, a long neurotoxin from the venom of the king cobra (Ophiophagus hannah)., Peng SS, Kumar TK, Jayaraman G, Chang CC, Yu C, J Biol Chem. 1997 Mar 21;272(12):7817-23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9065446 9065446]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Ophiophagus hannah]]
[[Category: Ophiophagus hannah]]
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[[Category: Single protein]]
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[[Category: Chang C-C]]
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[[Category: Chang, C C.]]
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[[Category: Jayaraman G]]
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[[Category: Jayaraman, G.]]
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[[Category: Kumar TKS]]
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[[Category: Kumar, T K.S.]]
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[[Category: Peng S-S]]
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[[Category: Peng, S S.]]
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[[Category: Yu C]]
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[[Category: Yu, C.]]
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[[Category: Multigene family]]
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[[Category: Neurotoxin]]
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[[Category: Toxin b]]
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[[Category: Venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:28:53 2008''
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Current revision

SOLUTION NMR STRUCTURE OF TOXIN B, A LONG NEUROTOXIN FROM THE VENOM OF THE KING COBRA, MINIMIZED AVERAGE STRUCTURE

PDB ID 1txa

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