1tx7

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[[Image:1tx7.gif|left|200px]]<br /><applet load="1tx7" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="1tx7, resolution 1.75&Aring;" />
 
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'''Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)'''<br />
 
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==Overview==
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==Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)==
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p-amidinophenylmethylphosphinic acid (AMPA) was designed, synthesized and crystallized in complex with trypsin to study interactions with the oxyanion hole at the S1 site. In comparison to benzamidine, AMPA shows improved activity, which the crystal structure demonstrates to result from hydrogen bonds between the negatively charged phosphinic acid group and the catalytic residues at the oxyanion hole.
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<StructureSection load='1tx7' size='340' side='right'caption='[[1tx7]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1tx7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TX7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4CM:(4-CARBAMIMIDOYLPHENYL)-METHYL-PHOSPHINIC+ACID'>4CM</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tx7 OCA], [https://pdbe.org/1tx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tx7 RCSB], [https://www.ebi.ac.uk/pdbsum/1tx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tx7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRY1_BOVIN TRY1_BOVIN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tx/1tx7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tx7 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1TX7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=4CM:'>4CM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TX7 OCA].
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*[[Trypsin 3D structures|Trypsin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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An oxyanion-hole selective serine protease inhibitor in complex with trypsin., Cui J, Marankan F, Fu W, Crich D, Mesecar A, Johnson ME, Bioorg Med Chem. 2002 Jan;10(1):41-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11738605 11738605]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Trypsin]]
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[[Category: Crich D]]
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[[Category: Crich, D.]]
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[[Category: Cui J]]
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[[Category: Cui, J.]]
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[[Category: Fu W]]
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[[Category: Fu, W.]]
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[[Category: Johnson ME]]
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[[Category: Johnson, M E.]]
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[[Category: Marankan F]]
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[[Category: Marankan, F.]]
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[[Category: Mesecar A]]
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[[Category: Mesecar, A.]]
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[[Category: 4CM]]
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[[Category: CA]]
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[[Category: bovine]]
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[[Category: p-amidinophenylmethylphosphinic acid (ampa)]]
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[[Category: trypsin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:18:17 2008''
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Current revision

Bovine Trypsin complexed with p-amidinophenylmethylphosphinic acid (AMPA)

PDB ID 1tx7

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