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1tyy

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{{Seed}}
 
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[[Image:1tyy.png|left|200px]]
 
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==Crystal structure of aminoimidazole riboside kinase from Salmonella enterica==
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The line below this paragraph, containing "STRUCTURE_1tyy", creates the "Structure Box" on the page.
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<StructureSection load='1tyy' size='340' side='right'caption='[[1tyy]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tyy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TYY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1tyy| PDB=1tyy | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tyy OCA], [https://pdbe.org/1tyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tyy RCSB], [https://www.ebi.ac.uk/pdbsum/1tyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tyy ProSAT]</span></td></tr>
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</table>
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===Crystal structure of aminoimidazole riboside kinase from Salmonella enterica===
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== Function ==
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[https://www.uniprot.org/uniprot/AIRSK_SALTY AIRSK_SALTY] Phosphorylates 5-amino-1-(beta-D-ribosyl)imidazole (AIRs) to form 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole (AIR), an important intermediate in the purine and thiamine biosynthetic pathways (PubMed:12486071). It allows the use of exogenous aminoimidazole riboside (AIRs) to satisfy the cellular requirement for purines and thiamine (PubMed:12486071).<ref>PMID:12486071</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_15458630}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 15458630 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ty/1tyy_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_15458630}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1TYY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium_lt2 Salmonella typhimurium lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TYY OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tyy ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Crystal structure of an aminoimidazole riboside kinase from Salmonella enterica: implications for the evolution of the ribokinase superfamily., Zhang Y, Dougherty M, Downs DM, Ealick SE, Structure. 2004 Oct;12(10):1809-21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15458630 15458630]
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<references/>
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[[Category: Fructokinase]]
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__TOC__
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[[Category: Salmonella typhimurium lt2]]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dougherty, M.]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Downs, D M.]]
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[[Category: Dougherty M]]
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[[Category: Ealick, S E.]]
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[[Category: Downs DM]]
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[[Category: Zhang, Y.]]
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[[Category: Ealick SE]]
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[[Category: Alpha/beta]]
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[[Category: Zhang Y]]
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[[Category: Ribokinase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:59:15 2008''
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Current revision

Crystal structure of aminoimidazole riboside kinase from Salmonella enterica

PDB ID 1tyy

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