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1u33
From Proteopedia
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| - | [[Image:1u33.png|left|200px]] | ||
| - | + | ==In situ extension as an approach for identifying novel alpha-amylase inhibitors== | |
| - | + | <StructureSection load='1u33' size='340' side='right'caption='[[1u33]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1u33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U33 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LM2:4-O-METHYL-MALTOSYL-ALPHA+(1,4)-(Z,+3S,4S,5R,6R)-3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-PIPERIDIN-2-ONE'>LM2</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u33 OCA], [https://pdbe.org/1u33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u33 RCSB], [https://www.ebi.ac.uk/pdbsum/1u33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u33 ProSAT]</span></td></tr> |
| - | [[1u33]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AMYP_HUMAN AMYP_HUMAN] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u33_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u33 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Amylase 3D structures|Amylase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Begum | + | [[Category: Large Structures]] |
| - | [[Category: Brayer | + | [[Category: Begum A]] |
| - | [[Category: Damager | + | [[Category: Brayer GD]] |
| - | [[Category: Li | + | [[Category: Damager I]] |
| - | [[Category: Numao | + | [[Category: Li C]] |
| - | [[Category: Overall | + | [[Category: Numao S]] |
| - | [[Category: Withers | + | [[Category: Overall CM]] |
| - | [[Category: Wrodnigg | + | [[Category: Withers SG]] |
| - | + | [[Category: Wrodnigg TM]] | |
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Current revision
In situ extension as an approach for identifying novel alpha-amylase inhibitors
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Categories: Homo sapiens | Large Structures | Begum A | Brayer GD | Damager I | Li C | Numao S | Overall CM | Withers SG | Wrodnigg TM
