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1u33

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{{Seed}}
 
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[[Image:1u33.png|left|200px]]
 
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==In situ extension as an approach for identifying novel alpha-amylase inhibitors==
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The line below this paragraph, containing "STRUCTURE_1u33", creates the "Structure Box" on the page.
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<StructureSection load='1u33' size='340' side='right'caption='[[1u33]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1u33]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U33 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LM2:4-O-METHYL-MALTOSYL-ALPHA+(1,4)-(Z,+3S,4S,5R,6R)-3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-PIPERIDIN-2-ONE'>LM2</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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{{STRUCTURE_1u33| PDB=1u33 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u33 OCA], [https://pdbe.org/1u33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u33 RCSB], [https://www.ebi.ac.uk/pdbsum/1u33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u33 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMYP_HUMAN AMYP_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/u3/1u33_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1u33 ConSurf].
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<div style="clear:both"></div>
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===In situ extension as an approach for identifying novel alpha-amylase inhibitors===
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==See Also==
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*[[Amylase 3D structures|Amylase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 15304511 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15304511}}
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==About this Structure==
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1U33 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U33 OCA].
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==Reference==
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<ref group="xtra">PMID:15304511</ref><references group="xtra"/>
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[[Category: Alpha-amylase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Begum, A.]]
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[[Category: Large Structures]]
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[[Category: Brayer, G D.]]
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[[Category: Begum A]]
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[[Category: Damager, I.]]
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[[Category: Brayer GD]]
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[[Category: Li, C.]]
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[[Category: Damager I]]
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[[Category: Numao, S.]]
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[[Category: Li C]]
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[[Category: Overall, C M.]]
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[[Category: Numao S]]
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[[Category: Withers, S G.]]
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[[Category: Overall CM]]
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[[Category: Wrodnigg, T M.]]
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[[Category: Withers SG]]
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[[Category: Acarbose]]
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[[Category: Wrodnigg TM]]
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[[Category: Enzyme mechanism]]
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[[Category: Glucosidase]]
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[[Category: Glycosidase]]
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[[Category: Human pancreatic alpha-amylase]]
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[[Category: Inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:50:53 2009''
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Current revision

In situ extension as an approach for identifying novel alpha-amylase inhibitors

PDB ID 1u33

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