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8sv1

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'''Unreleased structure'''
 
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The entry 8sv1 is ON HOLD
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==Caspase-1 complex with interleukin-18==
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<StructureSection load='8sv1' size='340' side='right'caption='[[8sv1]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8sv1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SV1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SV1 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sv1 OCA], [https://pdbe.org/8sv1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sv1 RCSB], [https://www.ebi.ac.uk/pdbsum/8sv1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sv1 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CASP1_HUMAN CASP1_HUMAN] Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.<ref>PMID:7876192</ref> <ref>PMID:15498465</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Dong Y]]
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[[Category: Jon K]]
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[[Category: Pascal D]]
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[[Category: Wu H]]

Current revision

Caspase-1 complex with interleukin-18

PDB ID 8sv1

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OCA

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