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8xob

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'''Unreleased structure'''
 
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The entry 8xob is ON HOLD
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==VMAT2 protonated state==
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<StructureSection load='8xob' size='340' side='right'caption='[[8xob]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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Authors: Jiang, D.H., Wu, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8xob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XOB FirstGlance]. <br>
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Description: transporter B
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xob OCA], [https://pdbe.org/8xob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xob RCSB], [https://www.ebi.ac.uk/pdbsum/8xob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xob ProSAT]</span></td></tr>
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[[Category: Wu, D]]
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</table>
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[[Category: Jiang, D.H]]
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== Disease ==
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[https://www.uniprot.org/uniprot/VMAT2_HUMAN VMAT2_HUMAN] Brain dopamine-serotonin vesicular transport disease. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/VMAT2_HUMAN VMAT2_HUMAN] Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:8643547, PubMed:23363473). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (PubMed:8860238) (By similarity).[UniProtKB:Q01827][UniProtKB:Q8BRU6]<ref>PMID:23363473</ref> <ref>PMID:8643547</ref> <ref>PMID:8860238</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jiang DH]]
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[[Category: Wu D]]

Current revision

VMAT2 protonated state

PDB ID 8xob

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