1h2c
From Proteopedia
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| - | <StructureSection load='1h2c' size='340' side='right' caption='[[1h2c]], [[Resolution|resolution]] 1.60Å' scene=''> | + | ==Ebola virus matrix protein VP40 N-terminal domain in complex with RNA (High-resolution VP40[55-194] variant).== |
| + | <StructureSection load='1h2c' size='340' side='right'caption='[[1h2c]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1h2c]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[1h2c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebola_virus_sp. Ebola virus sp.] and [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H2C FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h2c OCA], [https://pdbe.org/1h2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h2c RCSB], [https://www.ebi.ac.uk/pdbsum/1h2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h2c ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VP40_EBOZM VP40_EBOZM] Promotes virus assembly and budding by interacting with host proteins of the multivesicular body pathway. May facilitate virus budding by interacting with the nucleocapsid and the plasma membrane. Specific interactions with membrane-associated GP and VP24 during the budding process may also occur. The hexamer form seems to be involved in budding. The octamer form binds RNA, and may play a role in genome replication.<ref>PMID:15892969</ref> <ref>PMID:16719918</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 1h2c" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Ebola virus sp | + | [[Category: Ebola virus sp]] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Bracher | + | [[Category: Large Structures]] |
| - | [[Category: Dessen | + | [[Category: Bracher A]] |
| - | [[Category: Gomis-Ruth | + | [[Category: Dessen A]] |
| - | [[Category: Klenk | + | [[Category: Gomis-Ruth FX]] |
| - | [[Category: Weissenhorn | + | [[Category: Klenk HD]] |
| - | + | [[Category: Weissenhorn W]] | |
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Current revision
Ebola virus matrix protein VP40 N-terminal domain in complex with RNA (High-resolution VP40[55-194] variant).
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