1h3q

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{{Seed}}
 
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[[Image:1h3q.png|left|200px]]
 
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==Crystal structure of SEDL at 2.4 Angstroms resolution==
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The line below this paragraph, containing "STRUCTURE_1h3q", creates the "Structure Box" on the page.
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<StructureSection load='1h3q' size='340' side='right'caption='[[1h3q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h3q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H3Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h3q OCA], [https://pdbe.org/1h3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h3q RCSB], [https://www.ebi.ac.uk/pdbsum/1h3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h3q ProSAT]</span></td></tr>
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{{STRUCTURE_1h3q| PDB=1h3q | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TPPC2_MOUSE TPPC2_MOUSE] Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h3q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h3q ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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SEDL is an evolutionarily highly conserved protein in eukaryotic organisms. Deletions or point mutations in the SEDL gene are responsible for the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder. SEDL has been identified as a component of the transport protein particle (TRAPP), critically involved in endoplasmic reticulum-to-Golgi vesicle transport. Herein, we report the 2.4 A resolution structure of SEDL, which reveals an unexpected similarity to the structures of the N-terminal regulatory domain of two SNAREs, Ykt6p and Sec22b, despite no sequence homology to these proteins. The similarity and the presence of unusually many solvent-exposed apolar residues of SEDL suggest that it serves regulatory and/or adaptor functions through multiple protein-protein interactions. Of the four known missense mutations responsible for SEDT, three mutations (S73L, F83S, V130D) map to the protein interior, where the mutations would disrupt the structure, and the fourth (D47Y) on a surface at which the mutation may abrogate functional interactions with a partner protein.
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===CRYSTAL STURCTURE OF SEDL AT 2.4 ANGSTROMS RESOLUTION===
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Crystal structure of SEDL and its implications for a genetic disease spondyloepiphyseal dysplasia tarda.,Jang SB, Kim YG, Cho YS, Suh PG, Kim KH, Oh BH J Biol Chem. 2002 Dec 20;277(51):49863-9. Epub 2002 Oct 1. PMID:12361953<ref>PMID:12361953</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_12361953}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1h3q" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12361953 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12361953}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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1H3Q is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H3Q OCA].
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==Reference==
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<ref group="xtra">PMID:12361953</ref><references group="xtra"/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cho, Y S.]]
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[[Category: Cho Y-S]]
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[[Category: Jang, S B.]]
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[[Category: Jang SB]]
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[[Category: Kim, Y G.]]
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[[Category: Kim Y-G]]
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[[Category: Oh, B H.]]
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[[Category: Oh B-H]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Golgi]]
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[[Category: Sedl]]
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[[Category: Sedt]]
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[[Category: Vesicle transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 00:54:49 2009''
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Current revision

Crystal structure of SEDL at 2.4 Angstroms resolution

PDB ID 1h3q

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