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1oia

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==U1A rnp domain 1-95==
==U1A rnp domain 1-95==
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<StructureSection load='1oia' size='340' side='right' caption='[[1oia]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='1oia' size='340' side='right'caption='[[1oia]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1oia]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nrc 1nrc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OIA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OIA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1oia]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1nrc 1nrc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OIA FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1aud|1aud]], [[1cx0|1cx0]], [[1drz|1drz]], [[1dz5|1dz5]], [[1fht|1fht]], [[1m5k|1m5k]], [[1m5o|1m5o]], [[1m5p|1m5p]], [[1m5v|1m5v]], [[1nu4|1nu4]], [[1urn|1urn]], [[2u1a|2u1a]], [[3utr|3utr]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oia OCA], [http://pdbe.org/1oia PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1oia RCSB], [http://www.ebi.ac.uk/pdbsum/1oia PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1oia ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oia OCA], [https://pdbe.org/1oia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oia RCSB], [https://www.ebi.ac.uk/pdbsum/1oia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oia ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN]] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
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[https://www.uniprot.org/uniprot/SNRPA_HUMAN SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.<ref>PMID:9848648</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/1oia_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/1oia_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1oia" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1oia" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Evans, P R]]
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[[Category: Large Structures]]
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[[Category: Nagai, K]]
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[[Category: Evans PR]]
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[[Category: Nuclear protein]]
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[[Category: Nagai K]]
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[[Category: Ribonucleoprotein]]
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[[Category: Rna-binding]]
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Current revision

U1A rnp domain 1-95

PDB ID 1oia

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