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1w2c

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Current revision (09:09, 9 May 2024) (edit) (undo)
 
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<StructureSection load='1w2c' size='340' side='right'caption='[[1w2c]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='1w2c' size='340' side='right'caption='[[1w2c]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1w2c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W2C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1w2c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W2C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w2d|1w2d]], [[1w2f|1w2f]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Transferase Transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.7.127 2.1.7.127] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2c OCA], [https://pdbe.org/1w2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w2c RCSB], [https://www.ebi.ac.uk/pdbsum/1w2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w2c OCA], [https://pdbe.org/1w2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w2c RCSB], [https://www.ebi.ac.uk/pdbsum/1w2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w2c ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IP3KA_HUMAN IP3KA_HUMAN]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Transferase]]
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[[Category: Gonzalez B]]
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[[Category: Gonzalez, B]]
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[[Category: Irvine RF]]
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[[Category: Irvine, R F]]
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[[Category: Schell MJ]]
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[[Category: Schell, M J]]
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[[Category: Williams RL]]
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[[Category: Williams, R L]]
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[[Category: Amppnp]]
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[[Category: Inositol phosphate kinase]]
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[[Category: Ip3]]
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Current revision

Human Inositol (1,4,5) trisphosphate 3-kinase complexed with Mn2+/AMPPNP/Ins(1,4,5)P3

PDB ID 1w2c

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