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1w33

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[[Image:1w33.gif|left|200px]]<br />
 
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<applet load="1w33" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1w33, resolution 2.7&Aring;" />
 
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'''BBCRASP-1 FROM BORRELIA BURGDORFERI'''<br />
 
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==Overview==
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==BbCRASP-1 from Borrelia Burgdorferi==
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Borrelia burgdorferi, a spirochete transmitted to human hosts during, feeding of infected Ixodes ticks, is the causative agent of Lyme disease., Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form, of the disease and bind complement factor H (FH) and FH-like protein 1, (FHL-1) on the spirochete surface. Here we report the atomic structure for, the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer, that presents a novel target for drug design.
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<StructureSection load='1w33' size='340' side='right'caption='[[1w33]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1w33]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_ZS7 Borreliella burgdorferi ZS7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1W33 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1w33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w33 OCA], [https://pdbe.org/1w33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1w33 RCSB], [https://www.ebi.ac.uk/pdbsum/1w33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1w33 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O50957_BORBU O50957_BORBU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/w3/1w33_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1w33 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.
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==About this Structure==
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A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.,Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564<ref>PMID:15711564</ref>
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1W33 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi] with GOL as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W33 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15711564 15711564]
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</div>
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[[Category: Borrelia burgdorferi]]
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<div class="pdbe-citations 1w33" style="background-color:#fffaf0;"></div>
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[[Category: Single protein]]
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[[Category: Brade, V.]]
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[[Category: Cordes, F.S.]]
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[[Category: Goodstadt, L.]]
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[[Category: Kirschfink, M.]]
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[[Category: Kraiczy, P.]]
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[[Category: Lea, S.M.]]
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[[Category: Ponting, C.]]
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[[Category: Roversi, P.]]
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[[Category: Simon, M.M.]]
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[[Category: Skerka, C.]]
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[[Category: Wallich, R.]]
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[[Category: Zipfel, P.]]
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[[Category: GOL]]
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[[Category: complement regulator acquiring surface protein]]
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[[Category: factor h binding]]
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[[Category: lyme borreliosis]]
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[[Category: membrane protein]]
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[[Category: tick]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:26:24 2007''
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==See Also==
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*[[Complement Regulator-Acquiring Surface Protein|Complement Regulator-Acquiring Surface Protein]]
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*[[Complement regulator-acquiring surface protein|Complement regulator-acquiring surface protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Borreliella burgdorferi ZS7]]
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[[Category: Large Structures]]
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[[Category: Brade V]]
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[[Category: Cordes FS]]
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[[Category: Goodstadt L]]
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[[Category: Kirschfink M]]
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[[Category: Kraiczy P]]
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[[Category: Lea SM]]
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[[Category: Ponting C]]
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[[Category: Roversi P]]
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[[Category: Simon MM]]
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[[Category: Skerka C]]
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[[Category: Wallich R]]
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[[Category: Zipfel P]]

Current revision

BbCRASP-1 from Borrelia Burgdorferi

PDB ID 1w33

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