2bla

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==SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine==
==SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine==
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<StructureSection load='2bla' size='340' side='right' caption='[[2bla]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='2bla' size='340' side='right'caption='[[2bla]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2bla]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plavi Plavi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BLA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2bla]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BLA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BLA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1j3i|1j3i]], [[1j3j|1j3j]], [[1j3k|1j3k]], [[2bl9|2bl9]], [[2blb|2blb]], [[2blc|2blc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CP6:5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE'>CP6</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bla OCA], [https://pdbe.org/2bla PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bla RCSB], [https://www.ebi.ac.uk/pdbsum/2bla PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bla ProSAT], [https://www.topsan.org/Proteins/RSGI/2bla TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bla FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bla OCA], [http://pdbe.org/2bla PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bla RCSB], [http://www.ebi.ac.uk/pdbsum/2bla PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bla ProSAT], [http://www.topsan.org/Proteins/RSGI/2bla TOPSAN]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DRTS_PLAVI DRTS_PLAVI] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/2bla_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/2bla_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2bla" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2bla" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dihydrofolate reductase]]
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[[Category: Large Structures]]
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[[Category: Plavi]]
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[[Category: Chitnumsub, P]]
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[[Category: Khongsuk, P]]
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[[Category: Kongsaeree, P]]
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[[Category: Leartsakulpanich, U]]
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[[Category: Tarnchompoo, B]]
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[[Category: Walkinshaw, M D]]
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[[Category: Yuthavong, Y]]
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[[Category: Drug resistance]]
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[[Category: Malaria]]
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[[Category: Oxidoreductase]]
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[[Category: Plasmodium vivax]]
[[Category: Plasmodium vivax]]
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[[Category: Pyrimethamine]]
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[[Category: Chitnumsub P]]
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[[Category: Khongsuk P]]
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[[Category: Kongsaeree P]]
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[[Category: Leartsakulpanich U]]
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[[Category: Tarnchompoo B]]
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[[Category: Walkinshaw MD]]
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[[Category: Yuthavong Y]]

Current revision

SP21 double mutant P. vivax Dihydrofolate reductase in complex with pyrimethamine

PDB ID 2bla

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OCA

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