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2cl3
From Proteopedia
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| - | {{Seed}} | ||
| - | [[Image:2cl3.png|left|200px]] | ||
| - | + | ==Crystal structure of human Cleavage and Polyadenylation Specificity Factor 5 (CPSF5)== | |
| - | + | <StructureSection load='2cl3' size='340' side='right'caption='[[2cl3]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2cl3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CL3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cl3 OCA], [https://pdbe.org/2cl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cl3 RCSB], [https://www.ebi.ac.uk/pdbsum/2cl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cl3 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | === | + | [https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref> |
| - | + | == Evolutionary Conservation == | |
| - | + | [[Image:Consurf_key_small.gif|200px|right]] | |
| - | == | + | Check<jmol> |
| - | + | <jmolCheckbox> | |
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cl/2cl3_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cl3 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith C]] |
| - | [[Category: Berglund | + | [[Category: Berglund H]] |
| - | [[Category: Collins | + | [[Category: Collins R]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Ehn | + | [[Category: Ehn M]] |
| - | [[Category: Flodin | + | [[Category: Flodin S]] |
| - | [[Category: Flores | + | [[Category: Flores A]] |
| - | [[Category: Graslund | + | [[Category: Graslund S]] |
| - | [[Category: Hallberg | + | [[Category: Hallberg BM]] |
| - | [[Category: Hammarstrom | + | [[Category: Hammarstrom M]] |
| - | [[Category: Hogbom | + | [[Category: Hogbom M]] |
| - | [[Category: Kotenyova | + | [[Category: Holmberg Schiavone L]] |
| - | [[Category: Magnusdottir | + | [[Category: Kotenyova T]] |
| - | [[Category: Nilsson-Ehle | + | [[Category: Magnusdottir A]] |
| - | [[Category: Nordlund | + | [[Category: Nilsson-Ehle P]] |
| - | [[Category: Nyman | + | [[Category: Nordlund P]] |
| - | [[Category: Ogg | + | [[Category: Nyman T]] |
| - | [[Category: Persson | + | [[Category: Ogg D]] |
| - | [[Category: Sagemark | + | [[Category: Persson C]] |
| - | + | [[Category: Sagemark J]] | |
| - | [[Category: Stenmark | + | [[Category: Stenmark P]] |
| - | [[Category: Sundstrom | + | [[Category: Sundstrom M]] |
| - | [[Category: Thorsell | + | [[Category: Thorsell AG]] |
| - | [[Category: | + | [[Category: Van Den Berg S]] |
| - | [[Category: | + | [[Category: Wallden K]] |
| - | [[Category: | + | [[Category: Weigelt J]] |
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Current revision
Crystal structure of human Cleavage and Polyadenylation Specificity Factor 5 (CPSF5)
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Berglund H | Collins R | Edwards A | Ehn M | Flodin S | Flores A | Graslund S | Hallberg BM | Hammarstrom M | Hogbom M | Holmberg Schiavone L | Kotenyova T | Magnusdottir A | Nilsson-Ehle P | Nordlund P | Nyman T | Ogg D | Persson C | Sagemark J | Stenmark P | Sundstrom M | Thorsell AG | Van Den Berg S | Wallden K | Weigelt J
