2f77

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:28, 9 May 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2f77.jpg|left|200px]]
 
-
{{Structure
+
==Solution structure of the R55F mutant of M-PMV matrix protein (p10)==
-
|PDB= 2f77 |SIZE=350|CAPTION= <scene name='initialview01'>2f77</scene>
+
<StructureSection load='2f77' size='340' side='right'caption='[[2f77]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2f77]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_retrovirus_1 Simian retrovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F77 FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE= gag ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11942 Simian retrovirus 1])
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f77 OCA], [https://pdbe.org/2f77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f77 RCSB], [https://www.ebi.ac.uk/pdbsum/2f77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f77 ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=[[2f76|2F76]]
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2f77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f77 OCA], [http://www.ebi.ac.uk/pdbsum/2f77 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2f77 RCSB]</span>
+
[https://www.uniprot.org/uniprot/GAG_MPMV GAG_MPMV] p10 is the matrix protein. P14 is the nucleocapsid protein. p27 is the capsid protein.
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/2f77_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f77 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Despite extensive data demonstrating that immature retroviral particle assembly can take place either at the plasma membrane or at a distinct location within the cytoplasm, targeting of viral precursor proteins to either assembly site still remains poorly understood. Biochemical data presented here suggest that Tctex-1, a light chain of the molecular motor dynein, is involved in the intracellular targeting of Mason-Pfizer monkey virus (M-PMV) polyproteins to the cytoplasmic assembly site. Comparison of the three-dimensional structures of M-PMV wild-type matrix protein (wt MA) with a single amino acid mutant (R55F), which redirects assembly from a cytoplasmic site to the plasma membrane, revealed different mutual orientations of their C- and N-terminal domains. This conformational change buries a putative intracellular targeting motif located between both domains in the hydrophobic pocket of the MA molecule, thereby preventing the interaction with cellular transport mechanisms.
-
'''Solution structure of the R55F mutant of M-PMV matrix protein (p10)'''
+
D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein.,Vlach J, Lipov J, Rumlova M, Veverka V, Lang J, Srb P, Knejzlik Z, Pichova I, Hunter E, Hrabal R, Ruml T Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10565-70. Epub 2008 Jul 22. PMID:18647839<ref>PMID:18647839</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
==About this Structure==
+
</div>
-
2F77 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Simian_retrovirus_1 Simian retrovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F77 OCA].
+
<div class="pdbe-citations 2f77" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Simian retrovirus 1]]
[[Category: Simian retrovirus 1]]
-
[[Category: Single protein]]
+
[[Category: Hrabal R]]
-
[[Category: Hrabal, R.]]
+
[[Category: Hunter E]]
-
[[Category: Hunter, E.]]
+
[[Category: Lang J]]
-
[[Category: Lang, J.]]
+
[[Category: Lipov J]]
-
[[Category: Lipov, J.]]
+
[[Category: Ruml T]]
-
[[Category: Ruml, T.]]
+
[[Category: Rumlova M]]
-
[[Category: Rumlova, M.]]
+
[[Category: Srb P]]
-
[[Category: Srb, P.]]
+
[[Category: Veverka V]]
-
[[Category: Veverka, V.]]
+
[[Category: Vlach J]]
-
[[Category: Vlach, J.]]
+
-
[[Category: 4 alpha-helice]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:58:51 2008''
+

Current revision

Solution structure of the R55F mutant of M-PMV matrix protein (p10)

PDB ID 2f77

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f77"
Personal tools