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2ivx

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==CRYSTAL STRUCTURE OF HUMAN CYCLIN T2 AT 1.8 A RESOLUTION (CASP TARGET)==
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<StructureSection load='2ivx' size='340' side='right' caption='[[2ivx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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==Crystal structure of human cyclin T2 at 1.8 A resolution==
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<StructureSection load='2ivx' size='340' side='right'caption='[[2ivx]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ivx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IVX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ivx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IVX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ivx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ivx RCSB], [http://www.ebi.ac.uk/pdbsum/2ivx PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ivx OCA], [https://pdbe.org/2ivx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ivx RCSB], [https://www.ebi.ac.uk/pdbsum/2ivx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ivx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CCNT2_HUMAN CCNT2_HUMAN]] Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).<ref>PMID:10364329</ref>
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[https://www.uniprot.org/uniprot/CCNT2_HUMAN CCNT2_HUMAN] Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II).<ref>PMID:10364329</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/2ivx_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/2ivx_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ivx ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2ivx" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Cyclin|Cyclin]]
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*[[Cyclin 3D structures|Cyclin 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C]]
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[[Category: Large Structures]]
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[[Category: Berridge, G]]
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[[Category: Arrowsmith C]]
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[[Category: Bullock, A N]]
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[[Category: Berridge G]]
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[[Category: Das, S]]
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[[Category: Bullock AN]]
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[[Category: Debreczeni, J E]]
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[[Category: Das S]]
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[[Category: Delft, F Von]]
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[[Category: Debreczeni JE]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Fedorov, O]]
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[[Category: Fedorov O]]
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[[Category: Gorrec, F]]
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[[Category: Gorrec F]]
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[[Category: Knapp, S]]
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[[Category: Knapp S]]
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[[Category: Papagrigoriou, E]]
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[[Category: Papagrigoriou E]]
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[[Category: Pike, A C.W]]
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[[Category: Pike ACW]]
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[[Category: Savitsky, P]]
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[[Category: Savitsky P]]
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[[Category: Sundstrom, M]]
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[[Category: Sundstrom M]]
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[[Category: Turnbull, A]]
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[[Category: Turnbull A]]
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[[Category: Ugochukwu, E]]
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[[Category: Ugochukwu E]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Cell cycle]]
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[[Category: Von Delft F]]
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[[Category: Cell division]]
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[[Category: Cyclin]]
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[[Category: Nuclear protein]]
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[[Category: Phosphorylation]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Crystal structure of human cyclin T2 at 1.8 A resolution

PDB ID 2ivx

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