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2iyf

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==The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering==
==The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering==
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<StructureSection load='2iyf' size='340' side='right' caption='[[2iyf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='2iyf' size='340' side='right'caption='[[2iyf]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2iyf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_antibioticus"_waksman_and_woodruff_1941 "actinomyces antibioticus" waksman and woodruff 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IYF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2iyf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_antibioticus Streptomyces antibioticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IYF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ERY:ERYTHROMYCIN+A'>ERY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyf OCA], [http://pdbe.org/2iyf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2iyf RCSB], [http://www.ebi.ac.uk/pdbsum/2iyf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyf ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ERY:ERYTHROMYCIN+A'>ERY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iyf OCA], [https://pdbe.org/2iyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iyf RCSB], [https://www.ebi.ac.uk/pdbsum/2iyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iyf ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/OLED_STRAT OLED_STRAT] Specifically inactivates oleandomycin via 2'-O-glycosylation using UDP-glucose.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Glycosyltransferase|Glycosyltransferase]]
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces antibioticus waksman and woodruff 1941]]
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[[Category: Large Structures]]
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[[Category: Bolam, D N]]
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[[Category: Streptomyces antibioticus]]
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[[Category: Davies, G J]]
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[[Category: Bolam DN]]
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[[Category: Davis, B G]]
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[[Category: Davies GJ]]
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[[Category: Dodson, E J]]
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[[Category: Davis BG]]
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[[Category: Gilbert, H J]]
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[[Category: Dodson EJ]]
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[[Category: Martinez-Fleites, C]]
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[[Category: Gilbert HJ]]
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[[Category: Proctor, M R]]
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[[Category: Martinez-Fleites C]]
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[[Category: Roberts, S M]]
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[[Category: Proctor MR]]
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[[Category: Turkenburg, J P]]
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[[Category: Roberts SM]]
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[[Category: Yang, M]]
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[[Category: Turkenburg JP]]
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[[Category: Antibiotic resistance]]
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[[Category: Yang M]]
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[[Category: Carbohydrate]]
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[[Category: Enzyme]]
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[[Category: Glycosylation]]
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[[Category: Glycosyltransferase]]
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[[Category: Macrolide]]
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[[Category: Transferase]]
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Current revision

The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering

PDB ID 2iyf

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