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2izy

From Proteopedia

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==MOLECULAR BASIS OF AKAP SPECIFICITY FOR PKA REGULATORY SUBUNITS==
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<StructureSection load='2izy' size='340' side='right' caption='[[2izy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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==Molecular Basis of AKAP Specificity for PKA Regulatory Subunits==
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<StructureSection load='2izy' size='340' side='right'caption='[[2izy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2izy]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2IZY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2izy]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IZY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IZY FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2izy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izy OCA], [http://pdbe.org/2izy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2izy RCSB], [http://www.ebi.ac.uk/pdbsum/2izy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2izy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2izy OCA], [https://pdbe.org/2izy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2izy RCSB], [https://www.ebi.ac.uk/pdbsum/2izy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2izy ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAP2_MOUSE KAP2_MOUSE] Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/2izy_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iz/2izy_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[CAMP-dependent protein kinase|CAMP-dependent protein kinase]]
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: CAMP-dependent protein kinase]]
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[[Category: Mus musculus]]
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[[Category: Barford, D]]
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[[Category: Barford D]]
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[[Category: Carlson, C R]]
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[[Category: Carlson CR]]
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[[Category: Dokurno, P]]
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[[Category: Dokurno P]]
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[[Category: Gold, M G]]
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[[Category: Gold MG]]
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[[Category: Hoshi, N]]
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[[Category: Hoshi N]]
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[[Category: Lygren, B]]
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[[Category: Lygren B]]
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[[Category: Mcconnachie, G]]
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[[Category: McConnachie G]]
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[[Category: Scott, J D]]
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[[Category: Scott JD]]
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[[Category: Tasken, K]]
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[[Category: Tasken K]]
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[[Category: Camp]]
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[[Category: Camp- binding]]
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[[Category: D/d]]
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[[Category: Kinase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphorylation]]
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[[Category: Pka]]
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[[Category: Rii]]
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[[Category: Transferase]]
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Current revision

Molecular Basis of AKAP Specificity for PKA Regulatory Subunits

PDB ID 2izy

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